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题目:: Pdx-1-independent differentiation of mouse embryonic stem cells into insulin-expressing cells.
作者:: Takayama(I),Miyazaki(S),Tashiro(F),Fujikura(J),Miyazaki(J),Yamato(E)
状态:: 发布时间2008-02-01 , 更新时间 2013-11-21
期刊:: Diabetes Res Clin Pract
摘要:: To investigate whether insulin-producing cells obtained from ES cells via the nestin-positive cell-mediated method are of the pancreatic lineage, we established a pdx-1 knockout ES cell line and analyzed its differentiation into insulin-producing cells. As a result, pdx-1 knockout ES cell expressed insulin 2 gene at the final differentiated cells. Thus, our study demonstrated that pdx-1 is not essential for insulin gene expression, at least in cells differentiated from this population of nestin-expression enriched ES cells, and suggested that the insulin-producing cells derived from ES cells may be different from the pancreatic beta cells in terms of their lineage.
语言:: eng
DOI:: 10.1016/j.diabres.2007.08.013

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