Abstract
Heat-shock factor 1 (HSF1) is a transcription factor that is activated upon proteotoxic stress and coordinates induction of the heat-shock response. In this issue, Dai et al. (2007) show that HSF1 is a potent modifier of tumorigenesis and is required for tumor initiation and maintenance in a variety of cancer models. These findings add HSF1 to a growing list of non-oncogenes that could be exploited as cancer drug targets.
MeSH Terms
Animals
Carcinogens
Cell Line, Tumor
Cell Proliferation
Cell Survival
Cell Transformation, Neoplastic/genetics,metabolism,pathology
DNA-Binding Proteins/deficiency,genetics,metabolism
Gene Expression Regulation, Neoplastic
Genotype
Glucose/metabolism
Heat Shock Transcription Factors
Humans
Mice
Mice, Knockout
Mutation
Phenotype
Protein Biosynthesis
Proto-Oncogene Proteins c-sis/genetics,metabolism
Signal Transduction/genetics
Skin/metabolism,pathology
Skin Neoplasms/chemically induced,genetics,metabolism,pathology
Stress, Physiological/genetics,metabolism,pathology
Time Factors
Transcription Factors/deficiency,genetics,metabolism
Tumor Suppressor Protein p53/genetics,metabolism
ras Proteins/genetics,metabolism
Chemicals
Carcinogens
DNA-Binding Proteins
HSF1 protein, human
Heat Shock Transcription Factors
Hsf1 protein, mouse
Proto-Oncogene Proteins c-sis
Transcription Factors
Tumor Suppressor Protein p53
ras Proteins
Glucose
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Solimini Nicole L
Howard Hughes Medical Institute and Department of Genetics, Center for Genetics and Genomics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Luo Ji
Elledge Stephen J