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PMID: 17889643 Published · ppublish English Journal Article Comment

Non-oncogene addiction and the stress phenotype of cancer cells.

Cell ·Vol. 130 ·No. 6 ·2007-09-21 ·Pages 986-8

Solimini NL, Luo J, Elledge SJ

Abstract

Heat-shock factor 1 (HSF1) is a transcription factor that is activated upon proteotoxic stress and coordinates induction of the heat-shock response. In this issue, Dai et al. (2007) show that HSF1 is a potent modifier of tumorigenesis and is required for tumor initiation and maintenance in a variety of cancer models. These findings add HSF1 to a growing list of non-oncogenes that could be exploited as cancer drug targets.

MeSH Terms
Animals Carcinogens Cell Line, Tumor Cell Proliferation Cell Survival Cell Transformation, Neoplastic/genetics,metabolism,pathology DNA-Binding Proteins/deficiency,genetics,metabolism Gene Expression Regulation, Neoplastic Genotype Glucose/metabolism Heat Shock Transcription Factors Humans Mice Mice, Knockout Mutation Phenotype Protein Biosynthesis Proto-Oncogene Proteins c-sis/genetics,metabolism Signal Transduction/genetics Skin/metabolism,pathology Skin Neoplasms/chemically induced,genetics,metabolism,pathology Stress, Physiological/genetics,metabolism,pathology Time Factors Transcription Factors/deficiency,genetics,metabolism Tumor Suppressor Protein p53/genetics,metabolism ras Proteins/genetics,metabolism
Chemicals
Carcinogens DNA-Binding Proteins HSF1 protein, human Heat Shock Transcription Factors Hsf1 protein, mouse Proto-Oncogene Proteins c-sis Transcription Factors Tumor Suppressor Protein p53 ras Proteins Glucose
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Solimini Nicole L
Howard Hughes Medical Institute and Department of Genetics, Center for Genetics and Genomics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Luo Ji
Elledge Stephen J
Article Info
Journal
Cell
Abbr.
Cell
ISSN
0092-8674
Published
2007-09-21
Pages
986-8
Language
English
Region
United States
NLM ID
0413066
Subset
IM
Corrections
CommentOn
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