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PMID: 17870467 Published · ppublish English Comparative Study Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Structural basis of viral invasion: lessons from paramyxovirus F.

Current opinion in structural biology ·Vol. 17 ·No. 4 ·2007-08-00 ·Pages 427-36

Lamb RA, Jardetzky TS

Abstract

The structures of glycoproteins that mediate enveloped virus entry into cells have revealed dramatic structural changes that accompany membrane fusion and provided mechanistic insights into this process. The group of class I viral fusion proteins includes the influenza hemagglutinin, paramyxovirus F, HIV env, and other mechanistically related fusogens, but these proteins are unrelated in sequence and exhibit clearly distinct structural features. Recently determined crystal structures of the paramyxovirus F protein in two conformations, representing pre-fusion and post-fusion states, reveal a novel protein architecture that undergoes large-scale, irreversible refolding during membrane fusion, extending our understanding of this diverse group of membrane fusion machines.

MeSH Terms
Crystallography, X-Ray Membrane Fusion Microscopy, Electron Models, Molecular Paramyxoviridae/physiology Protein Conformation Protein Folding Structure-Activity Relationship Viral Fusion Proteins/chemistry,metabolism
Chemicals
Viral Fusion Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Lamb Robert A
Department of Biochemistry, Molecular Biology, Cell Biology, Northwestern University, Evanston, IL 60208, USA.
Jardetzky Theodore S
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Article Info
Journal
Current opinion in structural biology
Abbr.
Curr Opin Struct Biol
ISSN
0959-440X
DOI
10.1016/j.sbi.2007.08.016
Published
2007-08-00
Epub
2007-00-17
Pages
427-36
Language
English
Region
England
NLM ID
9107784
PMCID
PMC2086805
Subset
IM
Grants
NIGMS NIH HHS · R01 GM061050 · United States
NIGMS NIH HHS · R01 GM061050-05A2 · United States
NIGMS NIH HHS · R01 GM061050-06 · United States
External Links
PubMed source DOI: 10.1016/j.sbi.2007.08.016 PMC Full Text View journal details
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