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PMID: 1785140 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

Telomeres.

Trends in biochemical sciences ·Vol. 16 ·No. 10 ·1991-10-00 ·Pages 378-81

Blackburn EH

Abstract

Telomeres are specialized structures at the ends of eukaryotic linear chromosomes, consisting of protein-bound tandemly repeated simple DNA sequences. Telomeric DNA is unique in that it is copied from an RNA template that forms part of the enzyme, telomerase. This review discusses the synthesis and maintenance of these unusual structures.

MeSH Terms

Animals Base Sequence DNA/genetics DNA Nucleotidylexotransferase/physiology DNA Replication/physiology Humans Molecular Sequence Data Telomere/physiology

Chemicals

DNA DNA Nucleotidylexotransferase

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Blackburn E H

Department of Microbiology and Immunology, University of California, San Francisco 94143.

Article Info

Journal

Trends in biochemical sciences

Abbr.

Trends Biochem Sci

ISSN

0968-0004

DOI

10.1016/0968-0004(91)90155-o

Published

1991-10-00

Pages

378-81

Language

English

Region

England

NLM ID

7610674

Subset

Grants

NIGMS NIH HHS · GM26259 · United States

NIGMS NIH HHS · GM32565 · United States

External Links

PubMed source DOI: 10.1016/0968-0004(91)90155-o View journal details

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