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PMID: 17846136 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Emergence of the quinolone resistance-mediating gene aac(6')-Ib-cr in extended-spectrum-beta-lactamase-producing Klebsiella isolates collected in Slovenia between 2000 and 2005.

Antimicrobial agents and chemotherapy ·Vol. 51 ·No. 11 ·2007-11-00 ·Pages 4171-3

Ambrozic Avgustin J, Keber R, Zerjavic K, Orazem T, Grabnar M

Abstract

Seventy-four nonrepetitive uropathogenic fluoroquinolone-resistant or -intermediate extended-spectrum-beta-lactamase-producing Klebsiella isolates from Slovenia were screened for the presence of plasmid-mediated quinolone resistance genes. None of the known qnr genes were detected. The aac(6')-Ib-cr allele was detected on plasmids from 25 transconjugants for which the ciprofloxacin MIC was higher than for the recipient Escherichia coli strain.

MeSH Terms
Ciprofloxacin/pharmacology DNA, Bacterial/analysis,genetics Drug Resistance, Bacterial/genetics Enterobacteriaceae Infections/microbiology,urine Humans Klebsiella/drug effects,enzymology,growth & development Microbial Sensitivity Tests Plasmids/genetics Quinolones/pharmacology Slovenia beta-Lactamases/metabolism
Chemicals
DNA, Bacterial Quinolones Ciprofloxacin beta-Lactamases
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Ambrozic Avgustin Jerneja
Department of Biology, Biotechnical Faculty, University of Ljubljana, Vecna pot 111, 1000 Ljubljana, Slovenia. Jerneja.Ambrozic@bf.uni-lj.si
Keber Rok
Zerjavic Katja
Orazem Toni
Grabnar Miklavz
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.01480-06
Email
jerneja.ambrozic@bf.uni-lj.si
Published
2007-11-00
Epub
2007-00-10
Pages
4171-3
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC2151430
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.01480-06 PMC Full Text View journal details
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