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PMID: 17828272 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation.

Nature medicine ·Vol. 13 ·No. 10 ·2007-10-00 ·Pages 1173-5

Kebir H, Kreymborg K, Ifergan I, Dodelet-Devillers A, Cayrol R, Bernard M, Giuliani F, Arbour N, Becher B, Prat A

Abstract

T(H)17 lymphocytes appear to be essential in the pathogenesis of numerous inflammatory diseases. We demonstrate here the expression of IL-17 and IL-22 receptors on blood-brain barrier endothelial cells (BBB-ECs) in multiple sclerosis lesions, and show that IL-17 and IL-22 disrupt BBB tight junctions in vitro and in vivo. Furthermore, T(H)17 lymphocytes transmigrate efficiently across BBB-ECs, highly express granzyme B, kill human neurons and promote central nervous system inflammation through CD4+ lymphocyte recruitment.

MeSH Terms

Blood-Brain Barrier/drug effects,immunology CD4-Positive T-Lymphocytes/immunology Case-Control Studies Cell Membrane Permeability Cell Movement/immunology Cells, Cultured Central Nervous System/physiopathology Dose-Response Relationship, Drug Endothelial Cells/immunology,metabolism Endothelium, Vascular/immunology,metabolism Granzymes/immunology Humans Inflammation/etiology,physiopathology Interleukin-17/immunology,pharmacology Multiple Sclerosis/immunology,pathology Receptors, Interleukin/immunology T-Lymphocytes, Helper-Inducer/enzymology,immunology Tight Junctions/metabolism,pathology

Chemicals

Interleukin-17 Receptors, Interleukin interleukin-22 receptor Granzymes

Authors & Affiliations

10 authors, click to expand affiliations / ORCID

Kebir Hania

Neuroimmunology Unit, Center for the Study of Brain Diseases, Centre Hospitalier de l'Université de Montréal-Notre-Dame Hospital, 1560 Sherbrooke Street East, Montreal, Quebec H2L 4M1, Canada.

Kreymborg Katharina

Ifergan Igal

Dodelet-Devillers Aurore

Cayrol Romain

Bernard Monique

Giuliani Fabrizio

Arbour Nathalie

Becher Burkhard

Prat Alexandre

References (14)

14 references, click to expand

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Article Info

Journal

Nature medicine

Abbr.

Nat Med

ISSN

1078-8956

DOI

10.1038/nm1651

Published

2007-10-00

Epub

2007-00-09

Pages

1173-5

Language

English

Region

United States

NLM ID

9502015

PMCID

PMC5114125

Subset

Grants

Canadian Institutes of Health Research · 79785-1 · Canada

External Links

PubMed source DOI: 10.1038/nm1651 PMC Full Text View journal details

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Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation.

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