The maturation of rat brain myelin.

Lipids ·Vol. 3 ·No. 2 ·1968-03-00 ·Pages 157-62

Eng LF, Noble EP

Abstract

Myelin fractions were prepared from brains of 9- to 90-day-old rats by continuous and discontinuous sucrose density gradient procedures. Total protein and lipid content of myelin showed little variation, but lipid composition changed significantly during maturation. Cholesterol, galactolipids, and ethanolamine glycerophosphatide plasmalogen increased whereas choline glycerophosphatide content decreased with increasing age. The changes in lipid composition were more marked in the myelin prepared by the discontinuous gradient technique. The significance of these lipid changes in relation to their organization in the myelin membrane is discussed.

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Eng L F

Veterans Administration Hospital, 94304, Palo Alto, California.

Noble E P

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24 references, click to expand

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Article Info

Journal

Lipids

Abbr.

Lipids

ISSN

0024-4201

DOI

10.1007/BF02531734

Published

1968-03-00

Pages

157-62

Language

English

Region

United States

NLM ID

0060450

External Links

PubMed source DOI: 10.1007/BF02531734 View journal details

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The maturation of rat brain myelin.

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