Inhibition of protein synthesis in reticulocyte lysates by poliovirus.

The Journal of general virology ·Vol. 31 ·No. 1 ·1976-04-00 ·Pages 135-8

Racevskis J, Kerwar SS, Koch G

Abstract

Addition of 1 X 10(10) p.f.u. purified poliovirus to 100 mul of a rabbit reticulocyte lysate protein synthesizing system causes a complete inhibition of initiation of protein synthesis. This inhibition is not due to the viral RNA nor to any contaminants of the preparation, but is most likely caused by the viral coat protein.

MeSH Terms

Animals Blood Proteins/biosynthesis Cell-Free System Hot Temperature Poliovirus RNA, Viral/pharmacology Rabbits Reticulocytes/metabolism Viral Proteins/pharmacology

Chemicals

Blood Proteins RNA, Viral Viral Proteins

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Racevskis J

Kerwar S S

Koch G

Article Info

Journal

The Journal of general virology

Abbr.

J Gen Virol

ISSN

0022-1317

DOI

10.1099/0022-1317-31-1-135

Published

1976-04-00

Pages

135-8

Language

English

Region

England

NLM ID

0077340

Subset

External Links

PubMed source DOI: 10.1099/0022-1317-31-1-135 View journal details

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Inhibition of protein synthesis in reticulocyte lysates by poliovirus.

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