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题目:: Risk of cancer following immunosuppression in organ transplant recipients and in HIV-positive individuals in southern Europe.
作者:: Serraino(Diego),Piselli(Pierluca),Busnach(Ghil),Burra(Patrizia),Citterio(Franco),Arbustini(Eloisa),Baccarani(Umberto),De Juli(Emanuela),Pozzetto(Ubaldo),Bellelli(Stefania),Polesel(Jerry),Pradier(Christian),Dal Maso(Luigino),Angeletti(Claudio),Carrieri(Maria Patrizia),Rezza(Giovanni),Franceschi(Silvia),
状态:: 发布时间2007-09-17 , 更新时间 2007-09-17
期刊:: Eur J Cancer
摘要:: This investigation highlighted the risk of cancer in 8074 HIV-infected people and in 2875 transplant recipients in Italy and France. Observed and expected numbers of cancer were compared through sex- and age-standardised incidence ratios (SIRs) and 95% confidence intervals (CIs). After 15 years of follow-up, the cumulative probability of cancer was 14.7% in transplant recipients and 13.3% in HIV-positives. The SIRs for all cancers were 9.8 in HIV-positives and 2.2 in transplants. Kaposi's sarcoma (SIR=451 in HIV-positives, 125 in transplants) and non-Hodgkin lymphoma (SIR=62 and 11.1, respectively) were the most common cancers. A significantly increased SIR for liver cancer also emerged in both groups. The risk of lung cancer was significantly elevated in heart transplant recipients (SIR=2.8), and of borderline statistical significance in HIV-positive people (95% CI:0.9-2.8). Immune depression entails a two-fold increased overall risk of cancers, mainly related to cancers associated with a viral aetiology.
语言:: eng
DOI:: 10.1016/j.ejca.2007.07.015

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