Toward protein tertiary structure recognition by means of associative memory hamiltonians.

Science (New York, N.Y.) ·Vol. 246 ·No. 4928 ·1989-10-20 ·Pages 371-3

Friedrichs MS, Wolynes PG

Abstract

The statistical mechanics of associative memories and spin glasses suggests ways to design Hamiltonians for protein folding. An associative memory Hamiltonian based on hydrophobicity patterns is shown to have a large capacity for recall and to be capable of recognizing tertiary structure for moderately variant sequences.

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Friedrichs M S

Wolynes P G

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.246.4928.371

Published

1989-10-20

Pages

371-3

Language

English

Region

United States

NLM ID

0404511

External Links

PubMed source DOI: 10.1126/science.246.4928.371 View journal details

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