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PMID: 1774070 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Mapping of human chromosome 5 microsatellite DNA polymorphisms.

Genomics ·Vol. 11 ·No. 3 ·1991-11-00 ·Pages 695-700

Weber JL, Polymeropoulos MH, May PE, Kwitek AE, Xiao H, McPherson JD, Wasmuth JJ

Abstract

Thirteen moderately to highly informative microsatellite DNA polymorphisms based on (dC-dA)n.(dG-dT)n repeats were mapped to segments of human chromosome 5 using both linkage analysis and a panel of somatic cell hybrids which contained rearranged chromosomes. The markers were distributed throughout most of the length of the chromosome from the regions p15.3-p15.1 to q33.3-qter. Maps of the sites of meiotic recombination within the reference families proved particularly useful for the purpose of integrating new polymorphisms into the existing linkage map.

MeSH Terms
Base Sequence Chromosome Mapping Chromosomes, Human, Pair 5 Cloning, Molecular DNA, Satellite/genetics Female Genetic Linkage/genetics Humans Male Molecular Sequence Data Polymerase Chain Reaction Polymorphism, Genetic Recombination, Genetic/genetics
Chemicals
DNA, Satellite
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Weber J L
Marshfield Medical Research Foundation, Wisconsin 54449.
Polymeropoulos M H
May P E
Kwitek A E
Xiao H
McPherson J D
Wasmuth J J
Article Info
Journal
Genomics
Abbr.
Genomics
ISSN
0888-7543
Published
1991-11-00
Pages
695-700
Language
English
Region
United States
NLM ID
8800135
Subset
IM
Grants
NICHD NIH HHS · HD-18642 · United States
NHGRI NIH HHS · HG-00248 · United States
NHGRI NIH HHS · HG-00320 · United States
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