Living with p53, dying of p53.

Cell ·Vol. 130 ·No. 4 ·2007-08-24 ·Pages 597-600

Aylon Y, Oren M

Abstract

The p53 tumor suppressor protein acts as a major defense against cancer. Among its most distinctive features is the ability to elicit both apoptotic death and cell cycle arrest. In this issue of Cell, Das et al. (2007) and Tanaka et al. (2007) provide new insights into the mechanisms that dictate the life and death decisions of p53.

MeSH Terms

Apoptosis/genetics,physiology Cell Cycle/genetics,physiology Cell Death/genetics,physiology DNA Damage DNA-Binding Proteins Gene Expression Regulation, Neoplastic Models, Biological Neoplasms/genetics Protein Binding Tumor Suppressor Protein p53/genetics,physiology

Chemicals

DNA-Binding Proteins Tumor Suppressor Protein p53

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Aylon Yael

Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel.

Oren Moshe

Article Info

Journal

Cell

Abbr.

Cell

ISSN

0092-8674

DOI

10.1016/j.cell.2007.08.005

Published

2007-08-24

Pages

597-600

Language

English

Region

United States

NLM ID

0413066

Subset

Corrections

CommentOn

PMID: 17719541

CommentOn

PMID: 17719542

External Links

PubMed source DOI: 10.1016/j.cell.2007.08.005 View journal details

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Living with p53, dying of p53.

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