Home LiteratureArticle Details
PMID: 17705138 Published · ppublish English Journal Article Research Support, N.I.H., Extramural

Extensive HLA class I allele promiscuity among viral CTL epitopes.

European journal of immunology ·Vol. 37 ·No. 9 ·2007-09-00 ·Pages 2419-33

Frahm N, Yusim K, Suscovich TJ, Adams S, Sidney J, Hraber P, Hewitt HS, Linde CH, Kavanagh DG, Woodberry T, Henry LM, Faircloth K, Listgarten J, Kadie C, Jojic N, Sango K, Brown NV, Pae E, Zaman MT, Bihl F, Khatri A, John M, Mallal S, Marincola FM, Walker BD, Sette A, Heckerman D, Korber BT, Brander C

Abstract

Promiscuous binding of T helper epitopes to MHC class II molecules has been well established, but few examples of promiscuous class I-restricted epitopes exist. To address the extent of promiscuity of HLA class I peptides, responses to 242 well-defined viral epitopes were tested in 100 subjects regardless of the individuals' HLA type. Surprisingly, half of all detected responses were seen in the absence of the originally reported restricting HLA class I allele, and only 3% of epitopes were recognized exclusively in the presence of their original allele. Functional assays confirmed the frequent recognition of HLA class I-restricted T cell epitopes on several alternative alleles across HLA class I supertypes and encoded on different class I loci. These data have significant implications for the understanding of MHC class I-restricted antigen presentation and vaccine development.

MeSH Terms
Alleles Amino Acid Sequence Epitopes, T-Lymphocyte/chemistry,genetics,immunology HIV/immunology Histocompatibility Antigens Class I/genetics,immunology Humans Molecular Sequence Data T-Lymphocytes, Cytotoxic/immunology,metabolism
Chemicals
Epitopes, T-Lymphocyte Histocompatibility Antigens Class I
Authors & Affiliations
29 authors, click to expand affiliations / ORCID
Frahm Nicole
Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Yusim Karina
Suscovich Todd J
Adams Sharon
Sidney John
Hraber Peter
Hewitt Hannah S
Linde Caitlyn H
Kavanagh Daniel G
Woodberry Tonia
Henry Leah M
Faircloth Kellie
Listgarten Jennifer
Kadie Carl
Jojic Nebojsa
Sango Kaori
Brown Nancy V
Pae Eunice
Zaman M Tauheed
Bihl Florian
Khatri Ashok
John Mina
Mallal Simon
Marincola Francesco M
Walker Bruce D
Sette Alessandro
Heckerman David
Korber Bette T
Brander Christian
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Article Info
Journal
European journal of immunology
Abbr.
Eur J Immunol
ISSN
0014-2980
DOI
10.1002/eji.200737365
Published
2007-09-00
Pages
2419-33
Language
English
Region
Germany
NLM ID
1273201
PMCID
PMC2628559
Subset
IM
Grants
NIAID NIH HHS · R01 AI067077-01 · United States
NIAID NIH HHS · R21 AI055421 · United States
PHS HHS · R01-A1-067077 · United States
NIAID NIH HHS · F32 AI058457 · United States
PHS HHS · N01-AL-15422 · United States
NIAID NIH HHS · R01 AI067077-02 · United States
NIAID NIH HHS · R21-AI-055421-01-A1 · United States
NIAID NIH HHS · R01 AI067077-03 · United States
External Links
PubMed source DOI: 10.1002/eji.200737365 PMC Full Text View journal details
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