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PMID: 17693106 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Maternal influence in the transmission of asthma susceptibility.

Pulmonary pharmacology & therapeutics ·Vol. 21 ·No. 3 ·2008-00-00 ·Pages 474-84

Barrett EG

Abstract

Asthma is one of the most common chronic diseases in children, with increasing morbidity and mortality. A genetic predisposition and exposure to allergens have been implicated as major risk factors for the development of asthma. However, increasing evidence indicates that the mother plays a crucial role in mediating the development of fetal-infant immune responses to inhaled allergens. The exact nature and mechanism of this maternal influence and how it might be associated with the development of allergic sensitization and asthma are not clear. Under normal conditions, the maternal environment during pregnancy promotes an initial Th2 skewed immune response in the offspring which transitions to a nonallergic Th1 type response after birth. However, the allergic mother's influence may delay the normal transition to a nonallergic immune response to inhaled allergens in her children, thus increasing the risk for the development of allergic sensitization and/or asthma. Understanding the underlying mechanisms by which the maternal immune environment can influence the development of the fetal-infant immune response to inhaled allergens may lead to identifying new targets for the prevention of allergic sensitization and asthma.

MeSH Terms
Allergens/immunology Animals Antibodies/analysis,immunology Asthma/etiology,immunology Breast Feeding Female Humans Immunoglobulin G/metabolism Maternal-Fetal Exchange Mothers Natriuretic Peptides/physiology Pregnancy Pregnancy Complications/epidemiology Th1 Cells/immunology Th2 Cells/immunology
Chemicals
Allergens Antibodies Immunoglobulin G Natriuretic Peptides
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Barrett Edward G
Respiratory Immunology and Asthma Program, Lovelace Respiratory Research Institute, Albuquerque, NM 87108, USA. tbarrett@lrri.org <tbarrett@lrri.org>
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Article Info
Journal
Pulmonary pharmacology & therapeutics
Abbr.
Pulm Pharmacol Ther
ISSN
1094-5539
DOI
10.1016/j.pupt.2007.06.005
Email
tbarrett@lrri.org
Published
2008-00-00
Epub
2007-00-12
Pages
474-84
Language
English
Region
England
NLM ID
9715279
PMCID
PMC2478516
Subset
IM
Grants
NIAID NIH HHS · R01 AI061787-02 · United States
NIAID NIH HHS · R01 AI061787 · United States
NIAID NIH HHS · R01 AI061787-03 · United States
NIEHS NIH HHS · P30 ES012072 · United States
NIAID NIH HHS · R01 AI061787-01 · United States
NIAID NIH HHS · R01 AI061787-05 · United States
NIAID NIH HHS · R01 AI061787-04 · United States
NIEHS NIH HHS · P30 ES-012072 · United States
External Links
PubMed source DOI: 10.1016/j.pupt.2007.06.005 PMC Full Text View journal details
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