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PMID: 17629295 Published · ppublish English Journal Article Research Support, N.I.H., Extramural

Total synthesis of herboxidiene/GEX 1A.

Organic letters ·Vol. 9 ·No. 16 ·2007-08-02 ·Pages 3141-3

Zhang Y, Panek JS

Abstract

A convergent enantioselective synthesis of herboxidiene/GEX 1A (1) is described that features a double stereodifferentiating crotylation, [4 + 2] annulation, and a silicon-based sp2-sp2 cross-coupling to assemble the conjugated diene.

MeSH Terms

Antineoplastic Agents/chemical synthesis,chemistry,pharmacology Fatty Alcohols/chemical synthesis,chemistry,pharmacology Molecular Structure Pyrans/chemical synthesis,chemistry,pharmacology Stereoisomerism Streptomyces/chemistry

Chemicals

Antineoplastic Agents Fatty Alcohols Pyrans herboxidiene

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Zhang Yun

Department of Chemistry and Center for Chemical Methodology and Library Development, Metcalf Center for Science and Engineering, Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, USA.

Panek James S

References (10)

10 references, click to expand

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Article Info

Journal

Organic letters

Abbr.

Org Lett

ISSN

1523-7060

DOI

10.1021/ol701427k

Published

2007-08-02

Epub

2007-00-13

Pages

3141-3

Language

English

Region

United States

NLM ID

100890393

PMCID

PMC3164305

Subset

Grants

NIGMS NIH HHS · R01 GM055740 · United States

NIGMS NIH HHS · R01 GM055740-07 · United States

NIGMS NIH HHS · GM55740 · United States

External Links

PubMed source DOI: 10.1021/ol701427k PMC Full Text View journal details

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