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PMID: 17625513 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.

Nano-enabled synthetic biology.

Molecular systems biology ·Vol. 3 ·2007-00-00 ·Pages 125

Doktycz MJ, Simpson ML

Abstract

Biological systems display a functional diversity, density and efficiency that make them a paradigm for synthetic systems. In natural systems, the cell is the elemental unit and efforts to emulate cells, their components, and organization have relied primarily on the use of bioorganic materials. Impressive advances have been made towards assembling simple genetic systems within cellular scale containers. These biological system assembly efforts are particularly instructive, as we gain command over the directed synthesis and assembly of synthetic nanoscale structures. Advances in nanoscale fabrication, assembly, and characterization are providing the tools and materials for characterizing and emulating the smallest scale features of biology. Further, they are revealing unique physical properties that emerge at the nanoscale. Realizing these properties in useful ways will require attention to the assembly of these nanoscale components. Attention to systems biology principles can lead to the practical development of nanoscale technologies with possible realization of synthetic systems with cell-like complexity. In turn, useful tools for interpreting biological complexity and for interfacing to biological processes will result.

MeSH Terms
Nanostructures Nanotechnology Systems Biology/instrumentation
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Doktycz Mitchel J
Center for Nanophase Materials Sciences, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA. doktyczmj@ornl.gov
Simpson Michael L
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Article Info
Journal
Molecular systems biology
Abbr.
Mol Syst Biol
ISSN
1744-4292
DOI
10.1038/msb4100165
Email
doktyczmj@ornl.gov
Published
2007-00-00
Epub
2007-00-10
Pages
125
Language
English
Region
England
NLM ID
101235389
PMCID
PMC1948103
Subset
IM
Grants
NIBIB NIH HHS · R01 EB000657 · United States
NIBIB NIH HHS · EB000657 · United States
External Links
PubMed source DOI: 10.1038/msb4100165 PMC Full Text View journal details
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