Transcriptional partners in regulatory T cells: Foxp3, Runx and NFAT.

Trends in immunology ·Vol. 28 ·No. 8 ·2007-08-00 ·Pages 329-32

Hu H, Djuretic I, Sundrud MS, Rao A

Abstract

A general theme in gene regulation is that transcription factors never function alone. Recent studies have emphasized this concept for regulatory T cells, a unique lineage of CD4+ T cells that exert active immune suppression and are essential to maintaining self-tolerance.

MeSH Terms

Animals Core Binding Factor Alpha 2 Subunit/physiology Forkhead Transcription Factors/physiology Humans NFATC Transcription Factors/physiology T-Lymphocytes, Regulatory/metabolism Transcription Factor AP-1/physiology Transcription, Genetic

Chemicals

Core Binding Factor Alpha 2 Subunit FOXP3 protein, human Forkhead Transcription Factors NFATC Transcription Factors Transcription Factor AP-1

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Hu Hui

The CBR Institute for Biomedical Research and the Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.

Djuretic Ivana

Sundrud Mark S

Rao Anjana

Article Info

Journal

Trends in immunology

Abbr.

Trends Immunol

ISSN

1471-4906

DOI

10.1016/j.it.2007.06.006

Published

2007-08-00

Epub

2007-00-06

Pages

329-32

Language

English

Region

England

NLM ID

100966032

Subset

External Links

PubMed source DOI: 10.1016/j.it.2007.06.006 View journal details

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Transcriptional partners in regulatory T cells: Foxp3, Runx and NFAT.

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