| GeneLibs

题目:: Cancer genes associated with phenotypes in monoallelic and biallelic mutation carriers: new lessons from old players.
作者:: Rahman(Nazneen),Scott(Richard H)
状态:: 发布时间2007-07-06 , 更新时间 2013-11-21
期刊:: Hum Mol Genet
摘要:: Autosomal dominant cancer predisposition genes for common cancers such as breast cancer and colorectal cancer have been well recognized for over a decade. Monoallelic mutations in these genes are associated with high risks of adult-onset cancer. In recent years, it has become apparent that biallelic mutations in some of these genes, such as BRCA2, MSH2 and MLH1, result in distinctive phenotypes, including childhood cancer predisposition. Conversely, it has also become evident that some genes which cause autosomal recessive cancer predisposition syndromes such as Fanconi anaemia and ataxia-telangiectasia are associated with modestly increased risks of adult cancers in monoallelic mutation carriers. These observations raise interesting implications with respect to the identification and phenotypic characterization of cancer predisposition genes.
语言:: eng
DOI:: 10.1093/hmg/ddm026

文献库文献相关信息