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PMID: 176055 Published · ppublish English Journal Article

Does an inhibitor of mitochondrial adenylate kinase also affect oxidative phosphorylation?

Experientia ·Vol. 32 ·No. 3 ·1976-03-15 ·Pages 298-9

Lüstorff J, Schlimme E

Abstract

Adenylate kinase activity of intact mitochondria is strongly inhibited by Ap5A, i.e. p1,p5-Di (adenosine-5') pentaphosphate, whereas oxidative phosphorylation is not affected. Therefore, Ap5A is a useful tool to distinguish between oxidative and non oxidative ATP generating reactions.

MeSH Terms
Adenine Nucleotides/pharmacology Adenosine Diphosphate/pharmacology Adenylate Kinase/antagonists & inhibitors Animals Dinucleoside Phosphates Male Mitochondria, Liver/drug effects,metabolism Oxidative Phosphorylation/drug effects Phosphotransferases/antagonists & inhibitors Rats
Chemicals
Adenine Nucleotides Dinucleoside Phosphates P(1),P(5)-di(adenosine-5'-)pentaphosphate Adenosine Diphosphate Phosphotransferases Adenylate Kinase
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Lüstorff J
Schlimme E
References (5)
5 references, click to expand
  1. P 1 ,P 5 -Di(adenosine-5')pentaphosphate, a potent multisubstrate inhibitor of adenylate kinase.
    J Biol Chem. 1973 Feb 10;248(3):1121-3 PMID: 4734335
  2. Techniques for the application of polarography to mitochondrial respiration.
    Biochim Biophys Acta. 1961 Jan 1;46:134-42 PMID: 13710528
  3. Phosphorylation of bound adenosine monophosphate in the electron transfer particle, driven by succinate.
    Biochem Biophys Res Commun. 1965 Dec 21;21(6):537-42 PMID: 5879462
  4. Intramitochondrial intermembranal large amplitude protein movements. I. A possible novel aspect of membrane fluidity.
    Biochimie. 1974;56(6-7):907-24 PMID: 4374969
  5. Adenosine monophosphate as the first phosphoryl acceptor in oxidative phosphorylation.
    Arch Biochem Biophys. 1966 Nov;117(2):201-23 PMID: 5972817
Article Info
Journal
Experientia
Abbr.
Experientia
ISSN
0014-4754
DOI
10.1007/BF01940801
Published
1976-03-15
Pages
298-9
Language
English
Region
Switzerland
NLM ID
0376547
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01940801
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