Home LiteratureArticle Details
PMID: 1759904 Published · ppublish English Journal Article

Antigenic relationships among the 47 human adenoviruses determined in reference horse antisera.

Archives of virology ·Vol. 121 ·No. 1-4 ·1991-00-00 ·Pages 179-97

Hierholzer JC, Stone YO, Broderson JR

Abstract

Reference equine antisera to all 47 serotypes of human adenoviruses presently described have been prepared and evaluated by reciprocal neutralization and hemagglutination-inhibition tests. All tests were carried to endpoint dilutions a minimum of five times in each direction to give accurate values for homologous and heterologous antibody titers. Significant cross-reactions in the horse antisera were compared to similar data obtained from rabbit antisera. Using this analysis, major antigenic relationships exist among types 12-18-31 of subgenus A, types 7-11-14 and 34-35 of subgenus B, types 8-9-10, 10-19-37, 13-38-39, 15-22-42, 20-47, 24-32-33-46, and 29-45 of subgenus D, types 16-4 between subgenera B and E, and types 40-41 of subgenus F. Across all subgenera, types 8, 10, 13, 15, 17, 19, 26, 29, 39, 40, and 43 have antigenic moieties found most frequently in other types, averaging 12 heterologous reactions per type when summing both tests in both directions. Types 20, 30, 32, and 45 exhibit shared determinants slightly less often, with a mean of 8 heterologous reactions per type.

MeSH Terms
Adenoviruses, Human/classification Animals Antibodies, Viral/blood,immunology Antigens, Viral/immunology Cell Line Cross Reactions Hemagglutination Inhibition Tests Hemagglutination Tests Horses Humans Immune Sera Immunization Neutralization Tests Rabbits Serotyping
Chemicals
Antibodies, Viral Antigens, Viral Immune Sera
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Hierholzer J C
Division of Viral Diseases, Centers for Disease Control, Atlanta, Georgia.
Stone Y O
Broderson J R
References (65)
65 references, click to expand
  1. A new human adenovirus of subgenus D: candidate adenovirus type 42.
    Arch Virol. 1987;94(3-4):283-6 PMID: 3034212
  2. Molecular epidemiology of adenoviral conjunctivitis in Sapporo, Japan, and Manila, the Philippines.
    Jpn J Ophthalmol. 1987;31(4):538-46 PMID: 2834591
  3. Further subgrouping of the human adenoviruses by differential hemagglutination.
    J Infect Dis. 1973 Oct;128(4):541-50 PMID: 4743547
  4. Sequence and genetic organization of adenovirus type 35 early region 3.
    J Virol. 1988 Nov;62(11):4431-7 PMID: 3172347
  5. Examination of uncommon clinical isolates of human adenoviruses by restriction endonuclease analysis.
    J Clin Microbiol. 1985 Apr;21(4):611-6 PMID: 2985649
  6. Fatal disseminated adenovirus infection in a renal transplant recipient.
    Am J Med. 1975 Oct;59(4):591-8 PMID: 170822
  7. Characterization of candidate adenovirus 37 by SDS-polyacrylamide gel electrophoresis of virion polypeptides and DNA restriction site mapping.
    J Med Virol. 1981;7(2):119-25 PMID: 6267186
  8. Epidemic adenovirus keratoconjunctivitis.
    Lancet. 1978 Feb 25;1(8061):442-3 PMID: 75466
  9. Viral conjunctivitis with special reference to adenovirus type 37 and enterovirus 70 infection.
    Jpn J Ophthalmol. 1986;30(2):158-64 PMID: 3020290
  10. Keratoconjunctivitis associated with adenovirus type 37: an extended outbreak in an ophthalmologist's office.
    J Infect Dis. 1983 Feb;147(2):191-8 PMID: 6298314
  11. Immunological relationship among human adenoviruses of subgenus D.
    Arch Virol. 1982;72(3):199-209 PMID: 6180704
  12. Characterization of adenovirus isolates from AIDS patients.
    Ann N Y Acad Sci. 1984;437:161-74 PMID: 6099998
  13. Association of genital adenovirus infection with urethritis in men.
    Med J Aust. 1984 Sep 15;141(6):337-8 PMID: 6094996
  14. Evaluation of human adenoviruses 38, 39, 40, and 41 as new serotypes.
    Intervirology. 1988;29(1):1-10 PMID: 3384629
  15. Analysis of antigenically intermediate strains of subgenus B and D adenoviruses from AIDS patients.
    Arch Virol. 1988;103(1-2):99-115 PMID: 2850781
  16. New human adenovirus isolated from a renal transplant recipient: description and characterization of candiate adenovirus type 34.
    J Clin Microbiol. 1975 Apr;1(4):366-76 PMID: 170313
  17. Detection of enteric adenoviruses by dot-blot hybridization using a molecularly cloned viral DNA probe.
    J Med Virol. 1985 Jun;16(2):107-18 PMID: 2989418
  18. Enteric adenoviruses. Brief review.
    Arch Virol. 1986;88(1-2):1-17 PMID: 3006638
  19. Characterization of fastidious adenovirus types 40 and 41 by DNA restriction enzyme analysis and by neutralizing monoclonal antibodies.
    Virus Res. 1989 Feb;12(2):139-57 PMID: 2705331
  20. Immunological and biochemical characterization of human adenoviruses from subgenus B. II. DNA restriction analysis.
    Arch Virol. 1985;84(1-2):79-89 PMID: 2985033
  21. Generalized viral illness caused by an intermediate strain of adenovirus (21/H21 + 35).
    J Infect Dis. 1980 Mar;141(3):281-8 PMID: 6245153
  22. Vero microcultures for adenovirus neutralization tests.
    J Clin Microbiol. 1978 Jun;7(6):499-506 PMID: 670375
  23. Enzyme-linked immunosorbent assay for detection of enteric adenovirus 41.
    J Med Virol. 1985 Sep;17(1):19-27 PMID: 4045433
  24. New human adenovirus (candidate adenovirus type 35) causing fatal disseminated infection in a renal transplant recipient.
    J Clin Microbiol. 1977 Sep;6(3):257-65 PMID: 71305
  25. A large outbreak of epidemic keratoconjunctivitis: problems in controlling nosocomial spread.
    J Infect Dis. 1989 Dec;160(6):938-43 PMID: 2555421
  26. Comparison of immunization methods for producing reference adenovirus antisera in horses.
    Appl Microbiol. 1972 Sep;24(3):398-404 PMID: 4562476
  27. Comparative studies on aetiology and epidemiology of viral conjunctivitis in three countries of East Asia--Japan, Taiwan and South Korea.
    Int J Epidemiol. 1987 Mar;16(1):98-103 PMID: 3032816
  28. PRODUCTION OF ADENOVIRUS ANTISERUMS IN HORSES.
    Public Health Rep. 1965 Jul;80:647-52 PMID: 14310591
  29. DNA restriction analysis of adenovirus prototypes 1 to 41.
    Arch Virol. 1986;91(3-4):277-90 PMID: 3022681
  30. Cross-reactivity between enteric adenoviruses and adenovirus type 4: analysis of epitopes by solid-phase immune electron microscopy.
    J Gen Virol. 1983 Nov;64 (Pt 11):2517-20 PMID: 6196441
  31. Specific detection and typing of adenovirus types 40 and 41 in stool specimens by dot-blot hybridization.
    J Clin Microbiol. 1985 Dec;22(6):934-9 PMID: 2999189
  32. Adenovirus types 40 and 41 and rotaviruses associated with diarrhea in children from Guatemala.
    J Clin Microbiol. 1990 Aug;28(8):1780-4 PMID: 2168438
  33. Candidate adenoviruses 40 and 41: fastidious adenoviruses from human infant stool.
    J Med Virol. 1983;11(3):215-31 PMID: 6306161
  34. Restriction endonuclease mapping of adenovirus 35, a type isolated from immunocompromised hosts.
    J Virol. 1985 Nov;56(2):647-50 PMID: 2997485
  35. Hospital-associated epidemic of pharyngitis and conjunctivitis caused by adenovirus (21/H21 + 35).
    J Infect Dis. 1986 Oct;154(4):706-9 PMID: 3018096
  36. An outbreak of adenovirus keratoconjunctivitis in bristol.
    Br J Ophthalmol. 1979 Sep;63(9):621-6 PMID: 226115
  37. Comparison of monoclonal time-resolved fluoroimmunoassay with monoclonal capture-biotinylated detector enzyme immunoassay for adenovirus antigen detection.
    J Clin Microbiol. 1987 Sep;25(9):1662-7 PMID: 2821062
  38. Respiratory virus infection in immunocompromised patients.
    Bone Marrow Transplant. 1989 Jan;4(1):35-40 PMID: 2647186
  39. A combined enzyme immunoassay for rotavirus and adenovirus (EIARA).
    J Virol Methods. 1985 Jan;10(1):21-8 PMID: 2982891
  40. Enteric adenovirus 41 (Tak) requires low serum for growth in human primary cells.
    Virology. 1990 Sep;178(1):72-80 PMID: 2143875
  41. Adenovirus 38: a new human adenovirus species of subgenus D.
    Intervirology. 1984;22(3):164-9 PMID: 6094388
  42. Adenovirus isolates from urine of patients with acquired immunodeficiency syndrome.
    Lancet. 1983 Jun 11;1(8337):1293-6 PMID: 6134092
  43. Standardization and certification of reference antigens and antisera for 30 human adenovirus serotypes.
    Am J Epidemiol. 1967 Nov;86(3):617-33 PMID: 6081385
  44. The changing etiology of epidemic keratoconjunctivitis: antigenic and restriction enzyme analyses of adenovirus types 19 and 37 isolated over a 10-year period.
    J Infect Dis. 1983 Jul;148(1):24-33 PMID: 6309995
  45. Standardized viral hemagglutination and hemagglutination-inhibition tests. II. Description and statistical evaluation.
    Appl Microbiol. 1969 Nov;18(5):824-33 PMID: 4984203
  46. Importance of rotavirus and adenovirus types 40 and 41 in acute gastroenteritis in Korean children.
    J Clin Microbiol. 1990 Oct;28(10):2279-84 PMID: 2172286
  47. Adenovirus 37: identification and characterization of a medically important new adenovirus type of subgroup D.
    J Med Virol. 1981;7(2):105-18 PMID: 7264611
  48. Propagation and in vitro studies of previously non-cultivable enteral adenoviruses in 293 cells.
    Lancet. 1981 Oct 17;2(8251):832-4 PMID: 6116953
  49. Isolation of adenovirus type 34 from a renal transplant recipient with interstitial pneumonia.
    Transplantation. 1977 Feb;23(2):188-91 PMID: 189468
  50. Characteristics of noncultivable adenoviruses associated with diarrhea in infants: a new subgroup of human adenoviruses.
    J Clin Microbiol. 1979 Jul;10(1):96-103 PMID: 387812
  51. New human adenovirus (candidate adenovirus 36), a novel member of subgroup D.
    Arch Virol. 1980;64(3):225-33 PMID: 7406681
  52. NEUTRALIZATION OF THE ADENOVIRUSES TYPES 1 TO 28: SPECIFICITY AND ANTIGENIC RELATIONSHIPS.
    Arch Gesamte Virusforsch. 1965;15:188-99 PMID: 14269253
  53. New human adenovirus associated with respiratory illness: candidate adenovirus type 39.
    J Clin Microbiol. 1982 Jul;16(1):15-21 PMID: 6179962
  54. Laboratory identification of adenoviruses associated with gastroenteritis in Canada from 1983 to 1986.
    J Clin Microbiol. 1990 Jul;28(7):1525-9 PMID: 2166087
  55. Three adenovirus type 8 genome types defined by restriction enzyme analysis: prototype stability in geographically separated populations.
    J Clin Microbiol. 1986 Mar;23(3):469-74 PMID: 3007566
  56. Reference equine antisera to 33 human adenovirus types: homologous and heterologous titers.
    J Clin Microbiol. 1975 Jan;1(1):65-74 PMID: 1236869
  57. Molecular epidemiology of adenovirus type 35 infections in immunocompromised hosts.
    J Infect Dis. 1987 Jun;155(6):1127-34 PMID: 3033089
  58. The emerging role of adenoviruses as inducers of gastroenteritis.
    Pediatr Infect Dis. 1986 Jan-Feb;5(1 Suppl):S63-74 PMID: 3003720
  59. Observations on two new adenovirus serotypes with unusual antigenic characteristics.
    Am J Epidemiol. 1969 Dec;90(6):501-5 PMID: 5362858
  60. Adenovirus infections in patients undergoing bone-marrow transplantation.
    N Engl J Med. 1985 Feb 28;312(9):529-33 PMID: 2982098
  61. Adenoviruses from patients with AIDS: a plethora of serotypes and a description of five new serotypes of subgenus D (types 43-47).
    J Infect Dis. 1988 Oct;158(4):804-13 PMID: 2844918
  62. Aetiology and epidemiology of acute gastro-enteritis in Swedish children.
    J Infect. 1986 Jul;13(1):73-89 PMID: 3734469
  63. A new intermediate adenovirus type causing conjunctivitis.
    Arch Ophthalmol. 1979 Dec;97(12):2336-8 PMID: 229815
  64. Adjuvant formulation for use in vaccines to elicit both cell-mediated and humoral immunity.
    Vaccine. 1987 Sep;5(3):223-8 PMID: 3499713
  65. Immunological and biochemical characterization of human adenoviruses from subgenus B. I. Antigenic relationships.
    Arch Virol. 1985;84(1-2):63-78 PMID: 3985807
Article Info
Journal
Archives of virology
Abbr.
Arch Virol
ISSN
0304-8608
DOI
10.1007/BF01316753
Published
1991-00-00
Pages
179-97
Language
English
Region
Austria
NLM ID
7506870
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01316753 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2