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PMID: 17581577 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Base-excision repair of oxidative DNA damage.

Nature ·Vol. 447 ·No. 7147 ·2007-06-21 ·Pages 941-50

David SS, O'Shea VL, Kundu S

Abstract

Maintaining the chemical integrity of DNA in the face of assault by oxidizing agents is a constant challenge for living organisms. Base-excision repair has an important role in preventing mutations associated with a common product of oxidative damage to DNA, 8-oxoguanine. Recent structural studies have shown that 8-oxoguanine DNA glycosylases use an intricate series of steps to locate and excise 8-oxoguanine lesions efficiently against a high background of undamaged bases. The importance of preventing mutations associated with 8-oxoguanine is shown by a direct association between defects in the DNA glycosylase MUTYH and colorectal cancer. The properties of other guanine oxidation products and the associated DNA glycosylases that remove them are now also being revealed.

MeSH Terms
Animals Colorectal Neoplasms/genetics,metabolism DNA Damage DNA Glycosylases/metabolism DNA Repair DNA-(Apurinic or Apyrimidinic Site) Lyase/metabolism Guanine/analogs & derivatives,metabolism Humans
Chemicals
8-hydroxyguanine Guanine DNA Glycosylases mutY adenine glycosylase DNA-(Apurinic or Apyrimidinic Site) Lyase
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
David Sheila S
Department of Chemistry, University of California at Davis, 1 Shields Avenue, Davis, California 95616, USA. david@chem.ucdavis.edu
O'Shea Valerie L
Kundu Sucharita
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Article Info
Journal
Nature
Abbr.
Nature
ISSN
1476-4687
DOI
10.1038/nature05978
Email
david@chem.ucdavis.edu
Published
2007-06-21
Pages
941-50
Language
English
Region
England
NLM ID
0410462
PMCID
PMC2896554
Subset
IM
Grants
NIGMS NIH HHS · T32 GM008537 · United States
NCI NIH HHS · R01 CA090689-07 · United States
NCI NIH HHS · R01 CA067985 · United States
NCI NIH HHS · R01 CA067985-14 · United States
NCI NIH HHS · R01 CA090689 · United States
NCI NIH HHS · T32 CA093247 · United States
NCI NIH HHS · R01 CA067985-13 · United States
NCI NIH HHS · R01 CA090689-08 · United States
External Links
PubMed source DOI: 10.1038/nature05978 PMC Full Text View journal details
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