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PMID: 17570117 Published · ppublish English Journal Article Research Support, N.I.H., Extramural

The role of flagellin versus motility in acute lung disease caused by Pseudomonas aeruginosa.

The Journal of infectious diseases ·Vol. 196 ·No. 2 ·2007-07-15 ·Pages 289-96

Balloy V, Verma A, Kuravi S, Si-Tahar M, Chignard M, Ramphal R

Abstract

The flagellum of Pseudomonas aeruginosa has been implicated in acute pneumonia, and its flagellin is known to cause lung inflammation. However, its proinflammatory role, versus its motility function, as a cause of death by a whole bacterium has not been demonstrated. This issue was examined in a lung model of acute infection using different flagellar mutants. We found that the absence of motility does not significantly alter the LD(50), whereas the production of excess amounts of flagellin lowers it and results in early death. Next, we found that the absence of the Toll-like receptor 5 (TLR5) ligand, flagellin, results in slower clearance of this organism from the lungs and a delay in the time to death. These findings demonstrate the dual role of flagellin in host defense and in disease and suggest that the death in this model may be biphasic with flagellin playing a role early in the disease.

MeSH Terms

Acute Disease Animals Disease Models, Animal Flagellin/genetics,immunology Inflammation Lethal Dose 50 Mice Molecular Sequence Data Mutant Proteins Pneumonia/microbiology Pseudomonas Infections/immunology,pathology Pseudomonas aeruginosa/pathogenicity Survival Analysis Virulence

Chemicals

Mutant Proteins Flagellin

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Balloy Viviane

Institut Pasteur, Unité de Défense Innée et Inflammation, and INSERM U874, Paris, France.

Verma Amrisha

Kuravi Sudha

Si-Tahar Mustapha

Chignard Michel

Ramphal Reuben

Article Info

Journal

The Journal of infectious diseases

Abbr.

J Infect Dis

ISSN

0022-1899

DOI

10.1086/518610

Published

2007-07-15

Epub

2007-00-11

Pages

289-96

Language

English

Region

United States

NLM ID

0413675

Subset

Grants

NIAID NIH HHS · AI 45014 · United States

NIAID NIH HHS · AI 47852 · United States

Databases

GENBANK

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PubMed source DOI: 10.1086/518610 View journal details

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The role of flagellin versus motility in acute lung disease caused by Pseudomonas aeruginosa.

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