Thyroid gangliosides with high affinity for thyrotropin: potential role in thyroid regulation.

Science (New York, N.Y.) ·Vol. 199 ·No. 4324 ·1978-01-06 ·Pages 77-9

Mullin BR, Pacuszka T, Lee G, Kohn LD, Brady RO, Fishman PH

Abstract

Thyroid cell membranes contain a multiplicity of gangliosides, some of which inhibit thyrotropin binding to thyroid membranes. The most potent inhibitor is a ganglioside which is present in only trace amounts and appears to have a novel structure. Thyroid gangliosides may play a role in relaying the hormonal message to the thyroid cell.

MeSH Terms

Animals Cattle Cell Membrane/metabolism Gangliosides/chemistry,metabolism,pharmacology Sialic Acids/analysis Thyroid Gland/metabolism Thyrotropin/antagonists & inhibitors,metabolism

Chemicals

Gangliosides Sialic Acids Thyrotropin

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Mullin B R

Laboratory of Biochemical Pharmacology, National Institute of Arthritis, Metabolism, and Digestive Diseases, Bethesda, MD 20014, USA.

Pacuszka T

Lee G

Kohn L D

Brady R O

Fishman P H

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.199.4324.77

Published

1978-01-06

Pages

77-9

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.199.4324.77 View journal details

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Thyroid gangliosides with high affinity for thyrotropin: potential role in thyroid regulation.

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