Multifocal Scedosporium apiospermum spondylitis in a cystic fibrosis patient.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society ·Vol. 7 ·No. 1 ·2008-01-00 ·Pages 89-91

Guignard S, Hubert D, Dupont B, Anract P, Alioua D, Guerini H, Paugam A, Dougados M

Abstract

We report the first case of multifocal Scedosporium apiospermum spondylitis in a cystic fibrosis patient. The infection, which occurred during voriconazole prophylaxis, disseminated contiguously from the base of the left lung and pleura and spread to vertebrae via the epidural space. S. apiospermum osteoarticular infections are rare, and are difficult to diagnose and cure because of their resistance to anti-fungal drugs.

MeSH Terms

Adult Antifungal Agents/therapeutic use Caspofungin Cystic Fibrosis/complications,microbiology Drug Therapy, Combination Echinocandins/therapeutic use Humans Immunocompromised Host Lipopeptides Male Mycetoma/drug therapy Pleurisy/complications,microbiology Pyrimidines/therapeutic use Scedosporium/drug effects,pathogenicity Spondylitis/complications,drug therapy,microbiology Thoracic Vertebrae/microbiology Triazoles/therapeutic use Voriconazole

Chemicals

Antifungal Agents Echinocandins Lipopeptides Pyrimidines Triazoles Caspofungin Voriconazole

Authors & Affiliations

8 authors, click to expand affiliations / ORCID

Guignard S

Université René Descartes, Hôpital Cochin APHP, service de rhumatologie B, 27 rue du faubourg Saint Jacques, 75679 Paris cedex 14, France.

Hubert D

Dupont B

Anract P

Alioua D

Guerini H

Paugam A

Dougados M

Article Info

Journal

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

Abbr.

J Cyst Fibros

ISSN

1569-1993

DOI

10.1016/j.jcf.2007.05.003

Published

2008-01-00

Epub

2007-00-13

Pages

89-91

Language

English

Region

Netherlands

NLM ID

101128966

Subset

External Links

PubMed source DOI: 10.1016/j.jcf.2007.05.003 View journal details

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Multifocal Scedosporium apiospermum spondylitis in a cystic fibrosis patient.

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