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PMID: 17560335 Published · ppublish English Comparative Study Journal Article Research Support, N.I.H., Extramural

Genes that distinguish physiological and pathological angiogenesis.

Cancer cell ·Vol. 11 ·No. 6 ·2007-06-00 ·Pages 539-54

Seaman S, Stevens J, Yang MY, Logsdon D, Graff-Cherry C, St Croix B

Abstract

To unravel the normal vasculature transcriptome and determine how it is altered by neighboring malignant cells, we compared gene expression patterns of endothelial cells derived from the blood vessels of eight normal resting tissues, five tumors, and regenerating liver. Organ-specific endothelial genes were readily identified, including 27 from brain. We also identified 25 transcripts overexpressed in tumor versus normal endothelium, including 13 that were not found in the angiogenic endothelium of regenerating liver. Most of the shared angiogenesis genes have expected roles in cell-cycle control, but those specific for tumor endothelium were primarily cell surface molecules of uncertain function. These studies reveal striking differences between physiological and pathological angiogenesis potentially important for the development of tumor-specific, vascular-targeted therapies.

MeSH Terms
Animals Antigens, CD/metabolism B7 Antigens Biomarkers, Tumor/metabolism Cell Line, Tumor Endothelium, Vascular/metabolism Gene Expression Profiling Liver/metabolism Liver Neoplasms, Experimental/metabolism Liver Regeneration Mice Neovascularization, Pathologic/genetics Neovascularization, Physiologic/genetics Organ Specificity Receptors, Immunologic/metabolism
Chemicals
Antigens, CD B7 Antigens Biomarkers, Tumor CD276 protein, human Receptors, Immunologic
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Seaman Steven
Tumor Angiogenesis Section, Mouse Cancer Genetics Program, National Cancer Institute at Frederick, Frederick, MD 21702, USA.
Stevens Janine
Yang Mi Young
Logsdon Daniel
Graff-Cherry Cari
St Croix Brad
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Article Info
Journal
Cancer cell
Abbr.
Cancer Cell
ISSN
1535-6108
DOI
10.1016/j.ccr.2007.04.017
Published
2007-06-00
Pages
539-54
Language
English
Region
United States
NLM ID
101130617
PMCID
PMC2039723
Subset
IM
Grants
Intramural NIH HHS · Z01 BC010486-04 · United States
Corrections
CommentIn
PMID: 17560330
External Links
PubMed source DOI: 10.1016/j.ccr.2007.04.017 PMC Full Text View journal details
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