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PMID: 17541472 Published · ppublish English Journal Article

Stem cell fate analysis revisited: interpretation of individual clone dynamics in the light of a new paradigm of stem cell organization.

Journal of biomedicine & biotechnology ·Vol. 2007 ·No. 3 ·2007-00-00 ·Pages 84656

Roeder I, Braesel K, Lorenz R, Loeffler M

Abstract

Many experimental findings on heterogeneity, flexibility, and plasticity of tissue stem cells are currently challenging stem cell concepts that assume a cell intrinsically predefined, unidirectional differentiation program. In contrast to these classical concepts, nonhierarchical self-organizing systems provide an elegant and comprehensive alternative to explain the experimental data. Here we present the application of such a self-organizing concept to quantitatively describe the hematopoietic stem cell system. Focusing on the analysis of individual-stem-cell fates and clonal dynamics, we particularly discuss implications of the theoretical results on the interpretation of experimental findings. We demonstrate that it is possible to understand hematopoietic stem cell organization without assumptions on unidirectional developmental hierarchies, preprogrammed asymmetric division events or other assumptions implying the existence of a predetermined stem cell entity. The proposed perspective, therefore, changes the general paradigm of thinking about stem cells.

Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Roeder Ingo
Institute for Medical Informatics, Statistics and Epidemiology (IMISE), University of Leipzig, 04107 Leipzig, Germany.
Braesel Katrin
Lorenz Ronny
Loeffler Markus
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Article Info
Journal
Journal of biomedicine & biotechnology
Abbr.
J Biomed Biotechnol
ISSN
1110-7243
DOI
10.1155/2007/84656
Published
2007-00-00
Epub
2007-00-18
Pages
84656
Language
English
Region
United States
NLM ID
101135740
PMCID
PMC1874676
External Links
PubMed source DOI: 10.1155/2007/84656 PMC Full Text View journal details
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