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PMID: 17540480 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Adipokines and the blood-brain barrier.

Peptides ·Vol. 28 ·No. 6 ·2007-06-00 ·Pages 1317-30

Pan W, Kastin AJ

Abstract

Just as the blood-brain barrier (BBB) is not a static barrier, the adipocytes are not inert storage depots. Adipokines are peptides or polypeptides produced by white adipose tissue; they play important roles in normal physiology as well as in the metabolic syndrome. Adipokines secreted into the circulation can interact with the BBB and exert potent CNS effects. The specific transport systems for two important adipokines, leptin and tumor necrosis factor alpha, have been characterized during the past decade. By contrast, transforming growth factor beta-1 and adiponectin do not show specific permeation across the BBB, but modulate endothelial functions. Still others, like interleukin-6, may reach the brain but are rapidly degraded. This review summarizes current knowledge and recent findings of the rapidly growing family of adipokines and their interactions with the BBB.

MeSH Terms
Adipocytes/physiology Adiponectin/physiology Adipose Tissue, White/physiology Animals Blood-Brain Barrier Humans Interleukin-6/physiology Leptin/physiology Peptides/physiology Transforming Growth Factor beta/physiology Tumor Necrosis Factor-alpha/physiology
Chemicals
Adiponectin Interleukin-6 Leptin Peptides Transforming Growth Factor beta Tumor Necrosis Factor-alpha
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Pan Weihong
Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, United States. weihong.pan@pbrc.edu
Kastin Abba J
References (129)
129 references, click to expand
  1. Syntaxin 7 is localized to late endosome compartments, associates with Vamp 8, and Is required for late endosome-lysosome fusion.
    Mol Biol Cell. 2000 Sep;11(9):3137-53 PMID: 10982406
  2. Inhibition of tumor necrosis factor signal transduction in endothelial cells by dimethylaminopurine.
    J Biol Chem. 1996 Nov 8;271(45):28624-9 PMID: 8910494
  3. Diet-induced obese mice develop peripheral, but not central, resistance to leptin.
    J Clin Invest. 1997 Feb 1;99(3):385-90 PMID: 9022070
  4. Phenotype of the obese Koletsky (f) rat due to Tyr763Stop mutation in the extracellular domain of the leptin receptor (Lepr): evidence for deficient plasma-to-CSF transport of leptin in both the Zucker and Koletsky obese rat.
    Diabetes. 1997 Mar;46(3):513-8 PMID: 9032111
  5. Elevated levels of the complement components C3 and factor B in ventricular cerebrospinal fluid of patients with traumatic brain injury.
    J Neuroimmunol. 1997 Mar;73(1-2):63-9 PMID: 9058760
  6. IL-6 secreted by astroglial cells regulates Na-K-Cl cotransport in brain microvessel endothelial cells.
    Am J Physiol. 1997 Jun;272(6 Pt 1):C1829-35 PMID: 9227411
  7. Physiological response to long-term peripheral and central leptin infusion in lean and obese mice.
    Proc Natl Acad Sci U S A. 1997 Aug 5;94(16):8878-83 PMID: 9238071
  8. Blood-brain barrier permeability to ebiratide and TNF in acute spinal cord injury.
    Exp Neurol. 1997 Aug;146(2):367-73 PMID: 9270046
  9. Cerebrospinal fluid C3a increases with age, but does not increase further in Alzheimer's disease.
    Neurobiol Aging. 1997 Sep-Oct;18(5):555-7 PMID: 9390784
  10. Permeability of the blood-brain barrier to neurotrophins.
    Brain Res. 1998 Mar 30;788(1-2):87-94 PMID: 9554964
  11. Expression of leptin receptor isoforms in rat brain microvessels.
    Endocrinology. 1998 Aug;139(8):3485-91 PMID: 9681499
  12. Impaired blood-brain barrier function in angiotensinogen-deficient mice.
    Nat Med. 1998 Sep;4(9):1078-80 PMID: 9734405
  13. Different central and peripheral responses to leptin in rhesus monkeys: brain transport may be limited.
    J Clin Endocrinol Metab. 1998 Sep;83(9):3230-5 PMID: 9745433
  14. Upregulation of tumor necrosis factor alpha transport across the blood-brain barrier after acute compressive spinal cord injury.
    J Neurosci. 1999 May 1;19(9):3649-55 PMID: 10212323
  15. The proteasome, a novel protease regulated by multiple mechanisms.
    J Biol Chem. 1999 Aug 6;274(32):22123-6 PMID: 10428771
  16. De novo synthesis of diacylglycerol in endothelium may mediate the association between PAI-1 and the insulin resistance syndrome.
    Med Hypotheses. 2005;64(2):388-93 PMID: 15607575
  17. TNFR1 upregulation mediates tolerance after brain ischemic preconditioning.
    J Cereb Blood Flow Metab. 2005 Feb;25(2):193-203 PMID: 15647744
  18. Transport of transforming growth factor-beta 2 across the blood-brain barrier.
    Neuropharmacology. 2005 Feb;48(2):274-82 PMID: 15695166
  19. Leptin in the CNS: much more than a satiety signal.
    Neuropharmacology. 2003 Jun;44(7):845-54 PMID: 12726816
  20. Resistin promotes endothelial cell activation: further evidence of adipokine-endothelial interaction.
    Circulation. 2003 Aug 12;108(6):736-40 PMID: 12874180
  21. Interleukin-6 levels in the central nervous system are negatively correlated with fat mass in overweight/obese subjects.
    J Clin Endocrinol Metab. 2003 Sep;88(9):4379-83 PMID: 12970313
  22. Circulating TGF-beta1 does not cross the intact blood-brain barrier.
    J Mol Neurosci. 2003;21(1):43-8 PMID: 14500993
  23. Upregulation of p55 and p75 receptors mediating TNF-alpha transport across the injured blood-spinal cord barrier.
    J Mol Neurosci. 2003;21(2):173-84 PMID: 14593216
  24. Leptin signaling in the central nervous system and the periphery.
    Recent Prog Horm Res. 2004;59:305-31 PMID: 14749508
  25. Relaxin potentiates the expression of inducible nitric oxide synthase by endothelial cells from human umbilical vein in in vitro culture.
    Mol Hum Reprod. 2004 May;10(5):325-30 PMID: 15026539
  26. Insulin-mediated regulation of the endothelial renin-angiotensin system and vascular cell growth.
    J Hypertens. 2004 Jan;22(1):121-7 PMID: 15106803
  27. Adiponectin acts in the brain to decrease body weight.
    Nat Med. 2004 May;10(5):524-9 PMID: 15077108
  28. Transforming growth factor-beta1 upregulates the tight junction and P-glycoprotein of brain microvascular endothelial cells.
    Cell Mol Neurobiol. 2004 Jun;24(3):491-7 PMID: 15206827
  29. Why study transport of peptides and proteins at the neurovascular interface.
    Brain Res Brain Res Rev. 2004 Aug;46(1):32-43 PMID: 15297153
  30. An endotoxin-induced serum factor that causes necrosis of tumors.
    Proc Natl Acad Sci U S A. 1975 Sep;72(9):3666-70 PMID: 1103152
  31. Modulation of adipocyte differentiation by tumor necrosis factor and transforming growth factor beta.
    J Cell Biol. 1989 Mar;108(3):1105-13 PMID: 2921280
  32. Localization of cellular retinol-binding protein and retinol-binding protein in cells comprising the blood-brain barrier of rat and human.
    Proc Natl Acad Sci U S A. 1990 Jun;87(11):4265-9 PMID: 2190219
  33. Levels of acylation stimulating protein in obese women before and after moderate weight loss.
    Int J Obes. 1991 May;15(5):333-6 PMID: 1885258
  34. Resistin regulates human choriocarcinoma cell invasive behaviour and endothelial cell angiogenic processes.
    J Endocrinol. 2006 Jun;189(3):691-9 PMID: 16731799
  35. Adiponectin promotes endothelial cell differentiation from human peripheral CD14+ monocytes in vitro.
    J Cell Mol Med. 2006 Apr-Jun;10(2):459-69 PMID: 16796811
  36. Area postrema neurons are modulated by the adipocyte hormone adiponectin.
    J Neurosci. 2006 Sep 20;26(38):9695-702 PMID: 16988040
  37. Retinol-binding protein 4 in human obesity.
    Diabetes. 2006 Oct;55(10):2805-10 PMID: 17003346
  38. Brain adipocytokine action and metabolic regulation.
    Diabetes. 2006 Dec;55 Suppl 2:S145-54 PMID: 17130638
  39. Adiponectin complexes in human cerebrospinal fluid: distinct complex distribution from serum.
    Diabetologia. 2007 Mar;50(3):634-42 PMID: 17242917
  40. Endocrine role of the renin-angiotensin system in human adipose tissue and muscle: effect of beta-adrenergic stimulation.
    Hypertension. 2007 Mar;49(3):542-7 PMID: 17224474
  41. Corticotropin-releasing hormone receptor (CRHR)1 and CRHR2 are both trafficking and signaling receptors for urocortin.
    Mol Endocrinol. 2007 Mar;21(3):700-11 PMID: 17170072
  42. Adiponectin and resistin in human cerebrospinal fluid and expression of adiponectin receptors in the human hypothalamus.
    J Clin Endocrinol Metab. 2007 Mar;92(3):1129-36 PMID: 17213280
  43. TNFalpha trafficking in cerebral vascular endothelial cells.
    J Neuroimmunol. 2007 Apr;185(1-2):47-56 PMID: 17316829
  44. Urocortin trafficking in cerebral microvessel endothelial cells.
    J Mol Neurosci. 2007;31(2):171-81 PMID: 17478891
  45. Inhibition of transforming growth factor-beta production in brain pericytes contributes to cyclosporin A-induced dysfunction of the blood-brain barrier.
    Cell Mol Neurobiol. 2007 May;27(3):317-28 PMID: 17192829
  46. Convergent trafficking pattern of leptin after endocytosis mediated by ObRa-ObRd.
    J Cell Physiol. 2007 Jul;212(1):215-22 PMID: 17323382
  47. TNF reduces LIF endocytosis despite increasing NFkappaB-mediated gp130 expression.
    J Cell Physiol. 2007 Oct;213(1):161-6 PMID: 17443676
  48. Differential role of TNF receptors in cellular trafficking of intact TNF.
    Cell Physiol Biochem. 2007;20(5):559-68 PMID: 17762182
  49. Opposing effects of proteasomes and lysosomes on LIFR: modulation by TNF.
    J Mol Neurosci. 2007;32(1):80-9 PMID: 17873291
  50. Structural insights into phosphoinositide 3-kinase catalysis and signalling.
    Nature. 1999 Nov 18;402(6759):313-20 PMID: 10580505
  51. Impaired transport of leptin across the blood-brain barrier in obesity.
    Peptides. 1999 Nov;20(11):1341-5 PMID: 10612449
  52. Peptides crossing the blood-brain barrier: some unusual observations.
    Brain Res. 1999 Nov 27;848(1-2):96-100 PMID: 10612701
  53. Renin-dependent cardiovascular functions and renin-independent blood-brain barrier functions revealed by renin-deficient mice.
    J Biol Chem. 2000 Jan 7;275(1):5-8 PMID: 10617578
  54. Decreased transport of leptin across the blood-brain barrier in rats lacking the short form of the leptin receptor.
    Peptides. 1999 Dec;20(12):1449-53 PMID: 10698121
  55. Reduced body weight, adipose tissue, and leptin levels despite increased energy intake in female mice lacking acylation-stimulating protein.
    Endocrinology. 2000 Mar;141(3):1041-9 PMID: 10698180
  56. Obesity in the new millennium.
    Nature. 2000 Apr 6;404(6778):632-4 PMID: 10766249
  57. Influence of PAI-1 on adipose tissue growth and metabolic parameters in a murine model of diet-induced obesity.
    Arterioscler Thromb Vasc Biol. 2000 Apr;20(4):1150-4 PMID: 10764686
  58. A phosphatidylinositol 3-kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NFkappaB in human endothelial cells.
    J Biol Chem. 2000 May 19;275(20):15458-65 PMID: 10748004
  59. Partial saturation and regional variation in the blood-to-brain transport of leptin in normal weight mice.
    Am J Physiol Endocrinol Metab. 2000 Jun;278(6):E1158-65 PMID: 10827020
  60. A second look at the barriers of the medial basal hypothalamus.
    Exp Brain Res. 2000 May;132(1):10-26 PMID: 10836632
  61. Role of cytokines in the regulation of plasminogen activator inhibitor-1 expression and secretion in newly differentiated subcutaneous human adipocytes.
    Arterioscler Thromb Vasc Biol. 2000 Jun;20(6):1682-7 PMID: 10845889
  62. Evidence that collapsin response mediator protein-2 is involved in the dynamics of microtubules.
    J Biol Chem. 2000 Jun 16;275(24):17917-20 PMID: 10770920
  63. Fasting, but not adrenalectomy, reduces transport of leptin into the brain.
    Peptides. 2000 May;21(5):679-82 PMID: 10876050
  64. Plasminogen activator inhibitor 1, transforming growth factor-beta1, and BMI are closely associated in human adipose tissue during morbid obesity.
    Diabetes. 2000 Aug;49(8):1374-80 PMID: 10923640
  65. Phosphorylation of collapsin response mediator protein-2 by Rho-kinase. Evidence for two separate signaling pathways for growth cone collapse.
    J Biol Chem. 2000 Aug 4;275(31):23973-80 PMID: 10818093
  66. Unexpected amplification of leptin-induced Stat3 signaling by urocortin: implications for obesity.
    J Mol Neurosci. 2007;33(3):232-8 PMID: 17952632
  67. Selected contribution: circadian rhythm of tumor necrosis factor-alpha uptake into mouse spinal cord.
    J Appl Physiol (1985). 2002 Mar;92(3):1357-62; discussion 1356 PMID: 11842079
  68. Adiponectin, acylation stimulating protein and complement C3 are altered in obesity in very young children.
    Clin Endocrinol (Oxf). 2005 May;62(5):567-72 PMID: 15853826
  69. Tissue-type plasminogen activator crosses the intact blood-brain barrier by low-density lipoprotein receptor-related protein-mediated transcytosis.
    Circulation. 2005 May 3;111(17):2241-9 PMID: 15851587
  70. Evaluation of cerebrospinal fluid uPA, PAI-1, and soluble uPAR levels in HIV-infected patients.
    J Neuroimmunol. 2005 Jun;163(1-2):190-4 PMID: 15885322
  71. Leptin: a metabolic signal affecting central regulation of reproduction in the pig.
    Domest Anim Endocrinol. 2005 Jul;29(1):186-92 PMID: 15927773
  72. Effects of plasminogen activator inhibitor-1 on ischemic brain injury in permanent and thrombotic middle cerebral artery occlusion models in mice.
    J Thromb Haemost. 2005 Jul;3(7):1379-84 PMID: 15978095
  73. Central relaxin-3 administration causes hyperphagia in male Wistar rats.
    Endocrinology. 2005 Aug;146(8):3295-300 PMID: 15845619
  74. Pathophysiological levels of the obesity related peptides resistin and ghrelin increase adhesion molecule expression on human vascular endothelial cells.
    Clin Exp Pharmacol Physiol. 2005 Oct;32(10):839-44 PMID: 16173945
  75. Transforming growth factor beta1 release by human adipose tissue is enhanced in obesity.
    Metabolism. 2005 Nov;54(11):1546-51 PMID: 16253647
  76. Adiponectin does not cross the blood-brain barrier but modifies cytokine expression of brain endothelial cells.
    Diabetes. 2006 Jan;55(1):141-7 PMID: 16380487
  77. Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis.
    Neuron. 2006 Jan 19;49(2):191-203 PMID: 16423694
  78. Stroke upregulates TNFalpha transport across the blood-brain barrier.
    Exp Neurol. 2006 Mar;198(1):222-33 PMID: 16412421
  79. Differential BBB interactions of three ingestive peptides: obestatin, ghrelin, and adiponectin.
    Peptides. 2006 Apr;27(4):911-6 PMID: 16476508
  80. Intranasal leptin: blood-brain barrier bypass (BBBB) for obesity?
    Endocrinology. 2006 May;147(5):2086-7 PMID: 16617152
  81. Increased levels of acylation-stimulating protein in interleukin-6-deficient (IL-6(-/-)) mice.
    Endocrinology. 2006 Jun;147(6):2690-5 PMID: 16513824
  82. Denial versus dualism: the blood-brain barrier as an interface of the gut-brain axis.
    Endocrinology. 2006 Jun;147(6):2609-10 PMID: 16707729
  83. Extracellular signal-regulated kinase mediates phosphorylation of tropomyosin-1 to promote cytoskeleton remodeling in response to oxidative stress: impact on membrane blebbing.
    Mol Biol Cell. 2003 Apr;14(4):1418-32 PMID: 12686598
  84. Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss.
    J Clin Endocrinol Metab. 2000 Sep;85(9):3338-42 PMID: 10999830
  85. Activation of urocortin transport into brain by leptin.
    Peptides. 2000 Dec;21(12):1811-7 PMID: 11150641
  86. The hormone resistin links obesity to diabetes.
    Nature. 2001 Jan 18;409(6818):307-12 PMID: 11201732
  87. Novel roles for mammalian septins: from vesicle trafficking to oncogenesis.
    J Cell Sci. 2001 Mar;114(Pt 5):839-44 PMID: 11181167
  88. Glucose and insulin increase the transport of leptin through the blood-brain barrier in normal mice but not in streptozotocin-diabetic mice.
    Neuroendocrinology. 2001 Apr;73(4):237-42 PMID: 11340337
  89. Diurnal variation of leptin entry from blood to brain involving partial saturation of the transport system.
    Life Sci. 2001 May 4;68(24):2705-14 PMID: 11400913
  90. In vitro demonstration of a saturable transport system for leptin across the blood-brain barrier.
    Life Sci. 2001 May 25;69(1):67-73 PMID: 11411806
  91. Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor gamma agonists.
    J Biol Chem. 2001 Jul 13;276(28):25651-3 PMID: 11373275
  92. Increase in TNFalpha transport after SCI is specific for time, region, and type of lesion.
    Exp Neurol. 2001 Aug;170(2):357-63 PMID: 11476601
  93. Disruption of the plasminogen activator inhibitor 1 gene reduces the adiposity and improves the metabolic profile of genetically obese and diabetic ob/ob mice.
    FASEB J. 2001 Aug;15(10):1840-2 PMID: 11481248
  94. Roles of the cytoplasmic and transmembrane domains of syntaxins in intracellular localization and trafficking.
    J Cell Sci. 2001 Sep;114(Pt 17):3115-24 PMID: 11590238
  95. Angiotensinogen-deficient mice exhibit impairment of diet-induced weight gain with alteration in adipose tissue development and increased locomotor activity.
    Endocrinology. 2001 Dec;142(12):5220-5 PMID: 11713218
  96. Decreased resistin expression in mice with different sensitivities to a high-fat diet.
    Biochem Biophys Res Commun. 2001 Nov 30;289(2):564-7 PMID: 11716511
  97. Export from pericentriolar endocytic recycling compartment to cell surface depends on stable, detyrosinated (glu) microtubules and kinesin.
    Mol Biol Cell. 2002 Jan;13(1):96-109 PMID: 11809825
  98. Circulating relaxin acts on subfornical organ neurons to stimulate water drinking in the rat.
    Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1701-6 PMID: 11830674
  99. TNFalpha transport across the blood-brain barrier is abolished in receptor knockout mice.
    Exp Neurol. 2002 Apr;174(2):193-200 PMID: 11922661
  100. Upregulation of the transport system for TNFalpha at the blood-brain barrier.
    Arch Physiol Biochem. 2001 Oct;109(4):350-3 PMID: 11935370
  101. Phosphoinositides regulate membrane-dependent actin assembly by latex bead phagosomes.
    Mol Biol Cell. 2002 Apr;13(4):1190-202 PMID: 11950931
  102. Adipose tissue IL-6 content correlates with resistance to insulin activation of glucose uptake both in vivo and in vitro.
    J Clin Endocrinol Metab. 2002 May;87(5):2084-9 PMID: 11994345
  103. Intracerebroventricular interleukin-6 treatment decreases body fat in rats.
    Biochem Biophys Res Commun. 2002 Apr 26;293(1):560-5 PMID: 12054638
  104. Leptin transport across the blood-brain barrier of the Koletsky rat is not mediated by a product of the leptin receptor gene.
    Brain Res. 2002 Sep 20;950(1-2):130-6 PMID: 12231237
  105. Stress-induced regulation of eukaryotic elongation factor 2 kinase by SB 203580-sensitive and -insensitive pathways.
    Biochem J. 2002 Oct 15;367(Pt 2):525-32 PMID: 12171600
  106. Regulation of peptide-chain elongation in mammalian cells.
    Eur J Biochem. 2002 Nov;269(22):5360-8 PMID: 12423334
  107. Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs.
    EMBO J. 2002 Dec 2;21(23):6505-14 PMID: 12456657
  108. Selective increase in TNF alpha permeation across the blood-spinal cord barrier after SCI.
    J Neuroimmunol. 2003 Jan;134(1-2):111-7 PMID: 12507778
  109. Nutritionally induced obesity is attenuated in transgenic mice overexpressing plasminogen activator inhibitor-1.
    Arterioscler Thromb Vasc Biol. 2003 Jan 1;23(1):78-84 PMID: 12524228
  110. Novel peptide-peptide cooperation may transform feeding behavior.
    Peptides. 2002 Dec;23(12):2189-96 PMID: 12535698
  111. Increased hippocampal uptake of tumor necrosis factor alpha and behavioral changes in mice.
    Exp Brain Res. 2003 Mar;149(2):195-9 PMID: 12610687
  112. Activation of endothelial nitric-oxide synthase by tumor necrosis factor-alpha: a novel pathway involving sequential activation of neutral sphingomyelinase, phosphatidylinositol-3' kinase, and Akt.
    Mol Pharmacol. 2003 Apr;63(4):886-95 PMID: 12644590
  113. Interactions of cytokines with the blood-brain barrier: implications for feeding.
    Curr Pharm Des. 2003;9(10):827-31 PMID: 12678882
  114. Retinoids and retinoid-binding protein expression in rat adipocytes.
    J Biol Chem. 1992 Jan 25;267(3):1805-10 PMID: 1370481
  115. Ezrin contains cytoskeleton and membrane binding domains accounting for its proposed role as a membrane-cytoskeletal linker.
    J Cell Biol. 1993 Jan;120(1):129-39 PMID: 8416983
  116. Serine/threonine phosphorylation regulates binding of C hnRNP proteins to pre-mRNA.
    Proc Natl Acad Sci U S A. 1993 Aug 15;90(16):7764-8 PMID: 8356082
  117. The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B.
    Cell. 1994 Sep 9;78(5):773-85 PMID: 8087845
  118. A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B.
    EMBO J. 1994 Nov 15;13(22):5433-41 PMID: 7957109
  119. Peptides and the blood-brain barrier: the status of our understanding.
    Ann N Y Acad Sci. 1994 Oct 31;739:89-100 PMID: 7832500
  120. Penetration of interleukin-6 across the murine blood-brain barrier.
    Neurosci Lett. 1994 Sep 26;179(1-2):53-6 PMID: 7845624
  121. Wortmannin inhibits transcytosis of dimeric IgA by the polymeric immunoglobulin receptor.
    FEBS Lett. 1995 Nov 27;376(1-2):74-6 PMID: 8521971
  122. Cerebrovascular permeability to peptides: manipulations of transport systems at the blood-brain barrier.
    Pharm Res. 1995 Oct;12(10):1395-406 PMID: 8584471
  123. The history of neuropeptide research: version 5.a.
    Ann N Y Acad Sci. 1996 Mar 22;780:1-18 PMID: 8602723
  124. Tumor necrosis factor-alpha- and hyperglycemia-induced insulin resistance. Evidence for different mechanisms and different effects on insulin signaling.
    J Clin Invest. 1996 Mar 15;97(6):1471-7 PMID: 8617880
  125. Cerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans.
    Nat Med. 1996 May;2(5):589-93 PMID: 8616722
  126. Leptin enters the brain by a saturable system independent of insulin.
    Peptides. 1996;17(2):305-11 PMID: 8801538
  127. Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance.
    Lancet. 1996 Jul 20;348(9021):159-61 PMID: 8684156
  128. Comparison of saturable transport and extracellular pathways in the passage of interleukin-1 alpha across the blood-brain barrier.
    J Neuroimmunol. 1996 Jun;67(1):41-7 PMID: 8707929
  129. Differential permeability of the BBB in acute EAE: enhanced transport of TNT-alpha.
    Am J Physiol. 1996 Oct;271(4 Pt 1):E636-42 PMID: 8897850
Article Info
Journal
Peptides
Abbr.
Peptides
ISSN
0196-9781
DOI
10.1016/j.peptides.2007.04.023
Email
weihong.pan@pbrc.edu
Published
2007-06-00
Epub
2007-00-06
Pages
1317-30
Language
English
Region
United States
NLM ID
8008690
PMCID
PMC2040301
Subset
IM
Grants
NINDS NIH HHS · R01 NS045751-05 · United States
NINDS NIH HHS · NS46528 · United States
NIDDK NIH HHS · DK54880 · United States
NINDS NIH HHS · R01 NS046528-05 · United States
NINDS NIH HHS · R01 NS046528 · United States
NINDS NIH HHS · R01 NS045751 · United States
NIDDK NIH HHS · R01 DK054880 · United States
NINDS NIH HHS · NS45751 · United States
NIDDK NIH HHS · R56 DK054880 · United States
External Links
PubMed source DOI: 10.1016/j.peptides.2007.04.023 PMC Full Text View journal details
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