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PMID: 17537848 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural

Mamu-B*08-positive macaques control simian immunodeficiency virus replication.

Journal of virology ·Vol. 81 ·No. 16 ·2007-08-00 ·Pages 8827-32

Loffredo JT, Maxwell J, Qi Y, Glidden CE, Borchardt GJ, Soma T, Bean AT, Beal DR, Wilson NA, Rehrauer WM, Lifson JD, Carrington M, Watkins DI

Abstract

Certain major histocompatibility complex (MHC) class I alleles are associated with the control of human immunodeficiency virus and simian immunodeficiency virus (SIV) replication. We have designed sequence-specific primers for detection of the rhesus macaque MHC class I allele Mamu-B*08 by PCR and screened a cohort of SIV-infected macaques for this allele. Analysis of 196 SIV(mac)239-infected Indian rhesus macaques revealed that Mamu-B*08 was significantly overrepresented in elite controllers; 38% of elite controllers were Mamu-B*08 positive compared to 3% of progressors (P = 0.00001). Mamu-B*08 was also associated with a 7.34-fold decrease in chronic phase viremia (P = 0.002). Mamu-B*08-positive macaques may, therefore, provide a good model to understand the correlates of MHC class I allele-associated immune protection and viral containment in human elite controllers.

MeSH Terms
Alleles Animals Base Sequence Genetic Testing Histocompatibility Antigens Class I/genetics,metabolism Macaca mulatta Molecular Sequence Data Simian Acquired Immunodeficiency Syndrome/genetics,immunology Simian Immunodeficiency Virus/physiology Viremia/genetics,immunology Virus Replication
Chemicals
Histocompatibility Antigens Class I
Authors & Affiliations
13 authors, click to expand affiliations / ORCID
Loffredo John T
Wisconsin National Primate Research Center, University of Wisconsin-Madison, 555 Science Drive, Madison, WI 53711, USA.
Maxwell Jess
Qi Ying
Glidden Chrystal E
Borchardt Gretta J
Soma Taeko
Bean Alex T
Beal Dominic R
Wilson Nancy A
Rehrauer William M
Lifson Jeffrey D
Carrington Mary
Watkins David I
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.00895-07
Published
2007-08-00
Epub
2007-00-30
Pages
8827-32
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC1951344
Subset
IM
Grants
NCRR NIH HHS · C06 RR020141 · United States
NCRR NIH HHS · C06 RR015459 · United States
NCRR NIH HHS · P51 RR000167 · United States
NIAID NIH HHS · R01 AI052056 · United States
NCRR NIH HHS · R24 RR 016038 · United States
NCRR NIH HHS · R24 RR016038 · United States
NCRR NIH HHS · RR 15459-01 · United States
NCRR NIH HHS · P51 RR 000167 · United States
NCRR NIH HHS · RR 020141-01 · United States
NIAID NIH HHS · R01 AI 049120 · United States
Intramural NIH HHS · United States
NCRR NIH HHS · R24 RR015371 · United States
NIAID NIH HHS · R01 AI049120 · United States
NIAID NIH HHS · R01 AI 052056 · United States
NCI NIH HHS · N01CO12400 · United States
NCRR NIH HHS · R24 RR 015371 · United States
External Links
PubMed source DOI: 10.1128/JVI.00895-07 PMC Full Text View journal details
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