Compartmentalisation of EGFR signalling might potentiate the optimal use of EGFR tyrosine kinase inhibitors in cancer therapeutics.

British journal of cancer ·Vol. 96 ·No. 12 ·2007-06-18 ·Pages 1924-5

Karamouzis MV, Konstantinopoulos PA, Papavassiliou AG

Abstract

暂无摘要

MeSH Terms

Animals ErbB Receptors/physiology Humans Neoplasms/physiopathology Signal Transduction/physiology

Chemicals

ErbB Receptors

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Karamouzis M V

Konstantinopoulos P A

Papavassiliou A G

References (13)

13 references, click to expand

EGF-ERBB signalling: towards the systems level.
Nat Rev Mol Cell Biol. 2006 Jul;7(7):505-16 PMID: 16829981
Rab11-FIP2, an adaptor protein connecting cellular components involved in internalization and recycling of epidermal growth factor receptors.
J Biol Chem. 2002 Dec 20;277(51):49158-66 PMID: 12364336
Role of protein ubiquitylation in regulating endocytosis of receptor tyrosine kinases.
Oncogene. 2004 Mar 15;23(11):2057-70 PMID: 15021893
Role of rab5 in EGF receptor-mediated signal transduction.
Eur J Cell Biol. 2004 Jul;83(6):305-14 PMID: 15511088
rab7 activity affects epidermal growth factor:epidermal growth factor receptor degradation by regulating endocytic trafficking from the late endosome.
J Biol Chem. 2006 Jan 13;281(2):1099-106 PMID: 16282324
Nuclear EGFR signalling network in cancers: linking EGFR pathway to cell cycle progression, nitric oxide pathway and patient survival.
Br J Cancer. 2006 Jan 30;94(2):184-8 PMID: 16434982
Post-translational modifications and regulation of the RAS superfamily of GTPases as anticancer targets.
Nat Rev Drug Discov. 2007 Jul;6(7):541-55 PMID: 17585331
Abl tyrosine kinase regulates endocytosis of the epidermal growth factor receptor.
J Biol Chem. 2006 Oct 27;281(43):32714-23 PMID: 16943190
Get off my back! Rapid receptor internalization through circular dorsal ruffles.
Cancer Res. 2006 Dec 1;66(23):11094-6 PMID: 17145849
p38 kinase regulates epidermal growth factor receptor downregulation and cellular migration.
EMBO J. 2006 Dec 13;25(24):5683-92 PMID: 17139251
The tuberous sclerosis complex.
N Engl J Med. 2007 Jan 4;356(1):92-3; author reply 93-4 PMID: 17205617
Which biomarker predicts benefit from EGFR-TKI treatment for patients with lung cancer?
Br J Cancer. 2007 Mar 26;96(6):857-63 PMID: 17325698
Role of epidermal growth factor receptor degradation in gemcitabine-mediated cytotoxicity.
Oncogene. 2007 May 17;26(23):3431-9 PMID: 17146438

Article Info

Journal

British journal of cancer

Abbr.

Br J Cancer

ISSN

0007-0920

DOI

10.1038/sj.bjc.6603807

Published

2007-06-18

Epub

2007-00-22

Pages

1924-5

Language

English

Region

England

NLM ID

0370635

PMCID

PMC2359976

Subset

Corrections

CommentOn

PMID: 16434982

External Links

PubMed source DOI: 10.1038/sj.bjc.6603807 PMC Full Text View journal details

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Compartmentalisation of EGFR signalling might potentiate the optimal use of EGFR tyrosine kinase inhibitors in cancer therapeutics.

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