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PMID: 17446375 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Comment

Comment on "Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens".

Science (New York, N.Y.) ·Vol. 316 ·No. 5823 ·2007-04-20 ·Pages 370

Yu F, Hill RS, Schaffner SF, Sabeti PC, Wang ET, Mignault AA, Ferland RJ, Moyzis RK, Walsh CA, Reich D

Abstract

Mekel-Bobrov et al. (Reports, 9 September 2005, p. 1720) suggested that ASPM, a gene associated with microcephaly, underwent natural selection within the last 500 to 14,100 years. Their analyses based on comparison with computer simulations indicated that ASPM had an unusual pattern of variation. However, when we compare ASPM empirically to a large number of other loci, its variation is not unusual and does not support selection.

MeSH Terms

Adaptation, Biological Asians/genetics Biological Evolution Blacks/genetics Brain/anatomy & histology Gene Frequency Haplotypes Humans Nerve Tissue Proteins/genetics Polymorphism, Single Nucleotide Recombination, Genetic Selection, Genetic Sequence Analysis, DNA Time Whites/genetics

Chemicals

ASPM protein, human Nerve Tissue Proteins

Authors & Affiliations

10 authors, click to expand affiliations / ORCID

Yu Fuli

Department of Genetics, Harvard Medical School, New Research Building, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.

Hill R Sean

Schaffner Stephen F

Sabeti Pardis C

Wang Eric T

Mignault Andre A

Ferland Russell J

Moyzis Robert K

Walsh Christopher A

Reich David

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

1095-9203

DOI

10.1126/science.316.5823.370a

Published

2007-04-20

Pages

370

Language

English

Region

United States

NLM ID

0404511

Subset

Corrections

CommentOn

PMID: 16151010

External Links

PubMed source DOI: 10.1126/science.316.5823.370a View journal details

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