Benzimidazo[1,2-c][1,2,3]thiadiazole-7-sulfonamides as inhibitors of carbonic anhydrase.

Bioorganic & medicinal chemistry letters ·Vol. 17 ·No. 12 ·2007-06-15 ·Pages 3335-8

Dudutiene V, Baranauskiene L, Matulis D

Abstract

A series of benzimidazo[1,2-c][1,2,3]thiadiazole-7-sulfonamides were synthesized and their binding to two carbonic anhydrase isozymes measured by isothermal titration calorimetry (ITC). Human carbonic anhydrase I (hCAI) and bovine carbonic anhydrase II (bCAII) bound the inhibitors with observed association constants in the range from 1.1 x 10(6) to 2.6 x 10(7) M(-1).

MeSH Terms

Animals Benzimidazoles/chemical synthesis,pharmacology Binding Sites Calorimetry/methods Carbonic Anhydrase I/antagonists & inhibitors Carbonic Anhydrase II/antagonists & inhibitors Carbonic Anhydrase Inhibitors/chemical synthesis,pharmacology Cattle Humans Structure-Activity Relationship Sulfonamides/chemical synthesis,pharmacology Titrimetry/methods

Chemicals

Benzimidazoles Carbonic Anhydrase Inhibitors Sulfonamides Carbonic Anhydrase I Carbonic Anhydrase II

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Dudutiene Virginija

Laboratory of Biothermodynamics and Drug Design, Institute of Biotechnology, Vilnius LT-02241, Lithuania.

Baranauskiene Lina

Matulis Daumantas

Article Info

Journal

Bioorganic & medicinal chemistry letters

Abbr.

Bioorg Med Chem Lett

ISSN

0960-894X

DOI

10.1016/j.bmcl.2007.03.100

Published

2007-06-15

Epub

2007-00-05

Pages

3335-8

Language

English

Region

England

NLM ID

9107377

Subset

External Links

PubMed source DOI: 10.1016/j.bmcl.2007.03.100 View journal details

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Benzimidazo[1,2-c][1,2,3]thiadiazole-7-sulfonamides as inhibitors of carbonic anhydrase.

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