Trawling for treasure: tales of T-bet.

Nature immunology ·Vol. 8 ·No. 5 ·2007-05-00 ·Pages 448-50

Glimcher LH

Abstract

Discovering the transcription factors that direct lineage commitment in the T helper cell was a formidable task. Laurie Glimcher describes how she and Susanne Szabo hunted down T-bet, a transcription factor that is a 'master regulator' of commitment to the T helper type 1 lineage.

MeSH Terms

Cell Differentiation/immunology Cell Lineage/physiology T-Box Domain Proteins/metabolism Transcription Factors/metabolism

Chemicals

T-Box Domain Proteins T-box transcription factor TBX21 Transcription Factors

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Glimcher Laurie H

Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA. lglimche@hsph.harvard.edu

Article Info

Journal

Nature immunology

Abbr.

Nat Immunol

ISSN

1529-2908

DOI

10.1038/ni0507-448

lglimche@hsph.harvard.edu

Published

2007-05-00

Pages

448-50

Language

English

Region

United States

NLM ID

100941354

Subset

External Links

PubMed source DOI: 10.1038/ni0507-448 View journal details

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Trawling for treasure: tales of T-bet.

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