PLK1 inhibitors: setting the mitotic death trap.

Current biology : CB ·Vol. 17 ·No. 8 ·2007-04-17 ·Pages R280-3

Plyte S, Musacchio A

Abstract

Polo-like kinase 1 (Plk1) regulates mitotic progression in all eukaryotes and has been implicated in the transformation of human cells. Analysis of the cytological and anti-tumor activities of BI 2536, a novel, selective pharmacological inhibitor of Plk1, has connected chemistry and biology to the bedside.

MeSH Terms

Animals Antineoplastic Agents/pharmacology,therapeutic use Cell Cycle Proteins/antagonists & inhibitors Enzyme Inhibitors/pharmacology Humans Mitosis/drug effects Neoplasms/drug therapy Protein Serine-Threonine Kinases/antagonists & inhibitors Proto-Oncogene Proteins/antagonists & inhibitors Pteridines/pharmacology,therapeutic use

Chemicals

Antineoplastic Agents BI 2536 Cell Cycle Proteins Enzyme Inhibitors Proto-Oncogene Proteins Pteridines Protein Serine-Threonine Kinases polo-like kinase 1

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Plyte Simon

Congenia S.r.l., Genextra Group, Via Adamello 16, I-20139 Milan, Italy. simon.plyte@congenia.it

Musacchio Andrea

Article Info

Journal

Current biology : CB

Abbr.

Curr Biol

ISSN

0960-9822

DOI

10.1016/j.cub.2007.02.018

simon.plyte@congenia.it

Published

2007-04-17

Pages

R280-3

Language

English

Region

England

NLM ID

9107782

Subset

Corrections

CommentOn

PMID: 17291758

CommentOn

PMID: 17291761

External Links

PubMed source DOI: 10.1016/j.cub.2007.02.018 View journal details

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PLK1 inhibitors: setting the mitotic death trap.

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