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PMID: 174098 Published · ppublish English Case Reports Journal Article Research Support, U.S. Gov't, P.H.S.

Surface marker characteristics and Epstein-Barr virus studies of two established North American Burkitt's lymphoma cell lines.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 73 ·No. 1 ·1976-01-00 ·Pages 228-32

Epstein AL, Henle W, Henle G, Hewetson JF, Kaplan HS

Abstract

Tumor cell lines have been established in continuous culture from two North American Burkitt's lymphomas. The SU-AmB-1 line, derived from a patient with low serum antibody titers to Epstein-Barr virus (EBV), was devoid of EBV genomes by the reaction for EBV-associated nuclear antigen (EBNA), could not be induced to express EBV antigens, and was highly refractory to EBV superinfection. Conversely, the SU-AmB-2 cell line, derived from a patient with "African type" serology, yielded a positive EBNA reaction and was readily inducible and superinfectable. Although both cell lines possessed B (bone-marrow-derived) cell characteristics, they had different surface marker patterns. It is postulated that two different classes of undifferentiated B cell lymphomas exist, one of which is positive for the presence of EBV genomes and occurs endemically in Africa and New Guinea and sporadically in other parts of the world, the other of which is EBV-negative and occurs sporadically throughout the world, including the endemic areas.

MeSH Terms
Adolescent Africa Antigens, Viral/analysis Burkitt Lymphoma/immunology,pathology Cell Line Child Herpesvirus 4, Human/growth & development,immunology Humans Idoxuridine/pharmacology Immunoglobulin Fc Fragments/analysis Immunoglobulin M/analysis Lymphocyte Activation Male Receptors, Antigen, B-Cell/analysis United States
Chemicals
Antigens, Viral Immunoglobulin Fc Fragments Immunoglobulin M Receptors, Antigen, B-Cell Idoxuridine
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Epstein A L
Henle W
Henle G
Hewetson J F
Kaplan H S
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40 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.73.1.228
Published
1976-01-00
Pages
228-32
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC335874
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.73.1.228 PMC Full Text View journal details
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