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题目:: Germinal center helper T cells are dual functional regulatory cells with suppressive activity to conventional CD4+ T cells.
作者:: Marinova(Ekaterina),Han(Shuhua),Zheng(Biao)
状态:: 发布时间2007-04-03 , 更新时间 2011-11-17
期刊:: J Immunol
摘要:: Germinal center (GC) reaction is a T cell-dependent process in which activated B cells mature to produce high-affinity Abs and differentiate into memory B cells. The GC microenvironment is almost exclusively reserved for the optimal Ag-specific B cell clonal expansion, selection, and maturation, but lack significant conventional CD4(+) T cell responses. The mechanisms that ensure such a focused B cell response in the GC are not known. In this study, we report that human CD4(+)CD57(+) T cells, which are the major helper T cells in GCs, actively suppress the activation of conventional CD4(+) T cells, particularly Th1 cells, via a direct contact-dependent mechanism and soluble mediators. Our findings demonstrate that GC T cells are unique regulatory cells that provide critical help signals for B cell response but suppress conventional effector T cells in the same local environment.
语言:: eng
DOI:

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