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题目:: Cyclin D1 gene G870A polymorphism predicts response to neoadjuvant radiotherapy and prognosis in rectal cancer.
作者:: Ho-Pun-Cheung(Alexandre),Assenat(Eric),Thezenas(Simon),Bibeau(Frédéric),Rouanet(Philippe),Azria(David),Cellier(Dominic),Grenier(Jean),Ychou(Marc),Senesse(Pierre),Lopez-Crapez(Evelyne)
状态:: 发布时间2007-07-19 , 更新时间 2007-07-19
期刊:: Int J Radiat Oncol Biol Phys
摘要:: To investigate whether CCND1 genetic variations associated with a constitutive nuclear protein may influence either the pathologic response to preoperative RT or the prognosis in a series of rectal cancer patients.,Seventy rectal cancer patients treated by neoadjuvant radiotherapy were included in the study. CCND1 exon 5 mutations were screened, and the G870A polymorphism was assessed for correlation with clinical variables, tumor response, and patient outcome.,No exon 5 mutation was found. Concerning the G870A polymorphism, the A/A variant was significantly associated with radiosensitivity (p = 0.022). Moreover, patients harboring the A allele were correlated with a lower risk of local failure (p = 0.017). Also, combination of the G870A polymorphism with the post-therapeutic lymph node status allowed the elaboration of a prognostic index, which accurately distinguished subgroups of patients with predictable recurrence-free (p = 0.003) and overall (p = 0.044) survival.,Although CCND1 exon 5 mutations are rare in rectal cancer, G870A polymorphism is a frequent variation that may predict radiosensitivity and prognosis.
语言:: eng
DOI:: 10.1016/j.ijrobp.2007.01.022

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