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PMID: 17395794 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

A synthetic maternal-effect selfish genetic element drives population replacement in Drosophila.

Science (New York, N.Y.) ·Vol. 316 ·No. 5824 ·2007-04-27 ·Pages 597-600

Chen CH, Huang H, Ward CM, Su JT, Schaeffer LV, Guo M, Hay BA

Abstract

One proposed strategy for controlling the transmission of insect-borne pathogens uses a drive mechanism to ensure the rapid spread of transgenes conferring disease refractoriness throughout wild populations. Here, we report the creation of maternal-effect selfish genetic elements in Drosophila that drive population replacement and are resistant to recombination-mediated dissociation of drive and disease refractoriness functions. These selfish elements use microRNA-mediated silencing of a maternally expressed gene essential for embryogenesis, which is coupled with early zygotic expression of a rescuing transgene.

MeSH Terms
Adaptor Proteins, Signal Transducing/genetics,physiology Animals Antigens, Differentiation/genetics,physiology Crosses, Genetic DNA Transposable Elements Drosophila/embryology,genetics,physiology Drosophila Proteins/genetics,physiology Embryonic Development Female Gene Expression Genes, Insect Genetic Engineering Heterozygote Homozygote Male MicroRNAs/genetics Molecular Sequence Data RNA Interference Receptors, Immunologic/genetics,physiology Recombination, Genetic Repetitive Sequences, Nucleic Acid Transgenes Zygote/physiology
Chemicals
Adaptor Proteins, Signal Transducing Antigens, Differentiation DNA Transposable Elements Drosophila Proteins MicroRNAs Myd88 protein, Drosophila Receptors, Immunologic
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Chen Chun-Hong
Division of Biology, Mail Code 156-29, California Institute of Technology, Pasadena, CA 91125, USA.
Huang Haixia
Ward Catherine M
Su Jessica T
Schaeffer Lorian V
Guo Ming
Hay Bruce A
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
1095-9203
DOI
10.1126/science. 1138595
Published
2007-04-27
Epub
2007-00-29
Pages
597-600
Language
English
Region
United States
NLM ID
0404511
Subset
IM
Grants
NIGMS NIH HHS · GM057422 · United States
NIGMS NIH HHS · GM70956 · United States
NINDS NIH HHS · NS042580 · United States
NINDS NIH HHS · NS048396 · United States
Databases
GENBANK
EF447105, EF447106
External Links
PubMed source DOI: 10.1126/science. 1138595 View journal details
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