Germinal centres in T-cell-dependent antibody responses.

Immunology today ·Vol. 13 ·No. 1 ·1992-01-00 ·Pages 17-21

Liu YJ, Johnson GD, Gordon J, MacLennan IC

Abstract

For more than a century follicles have been recognized as a site of intense cell proliferation and cell death. At last the significance of this activity is beginning to emerge: antigen-driven B-cell proliferation, somatic mutation, positive and negative selection, and memory and plasma cell development all appear to take place within the follicle.

MeSH Terms

Animals Antibody Formation B-Lymphocytes/immunology Humans Lymphoid Tissue/cytology,immunology Mutation Selection, Genetic T-Lymphocytes/immunology

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Liu Y J

Dept of Immunology, University of Birmingham Medical School, UK.

Johnson G D

Gordon J

MacLennan I C

Article Info

Journal

Immunology today

Abbr.

Immunol Today

ISSN

0167-5699

DOI

10.1016/0167-5699(92)90199-H

Published

1992-01-00

Pages

17-21

Language

English

Region

England

NLM ID

8008346

Subset

External Links

PubMed source DOI: 10.1016/0167-5699(92)90199-H

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