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PMID: 173864 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Attenuation of herpesvirus saimiri for marmosets after successive passage in cell culture at 39 degrees C.

Journal of the National Cancer Institute ·Vol. 55 ·No. 5 ·1975-11-00 ·Pages 1243-6

Schaffer PA, Falk LA, Deinhardt F

Abstract

A variant of Herpesvirus saimiri (HVS) stably attenuated for marmosets was isolated after serial passage of wild-type HVS in cell culture at 39 degrees C. Marmosets previously inoculated with attenuated virus experienced a significant delay in the development of lymphoma when challenged with wild-type HVS.

MeSH Terms

Animals Antibody Formation Callitrichinae/immunology Cells, Cultured Herpesviridae/immunology Herpesvirus 2, Saimiriine/immunology Hot Temperature Lymphoma/immunology Neoplasms, Experimental/immunology Vaccination Vaccines, Attenuated Viral Vaccines

Chemicals

Vaccines, Attenuated Viral Vaccines

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Schaffer P A

Falk L A

Deinhardt F

Article Info

Journal

Journal of the National Cancer Institute

Abbr.

J Natl Cancer Inst

ISSN

0027-8874

DOI

10.1093/jnci/55.5.1243

Published

1975-11-00

Pages

1243-6

Language

English

Region

United States

NLM ID

7503089

Subset

External Links

PubMed source DOI: 10.1093/jnci/55.5.1243 View journal details

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Attenuation of herpesvirus saimiri for marmosets after successive passage in cell culture at 39 degrees C.

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