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PMID: 17384647 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Mouse Piwi-interacting RNAs are 2'-O-methylated at their 3' termini.

Nature structural & molecular biology ·Vol. 14 ·No. 4 ·2007-04-00 ·Pages 347-8

Kirino Y, Mourelatos Z

Abstract

Piwi-interacting RNAs (piRNAs) are a novel class of small RNAs that are expressed specifically and abundantly in male germ cells. Here we report that the 3' termini of piRNAs are 2'-O-methylated; this modification may have important implications for the biogenesis and function of piRNAs.

MeSH Terms

Animals Argonaute Proteins Male Methylation Mice Phosphates/metabolism Proteins/metabolism RNA/chemistry,metabolism RNA Processing, Post-Transcriptional Testis/metabolism

Chemicals

Argonaute Proteins Phosphates Piwil1 protein, mouse Proteins RNA

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Kirino Yohei

Department of Pathology and Laboratory Medicine, Division of Neuropathology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

Mourelatos Zissimos

Article Info

Journal

Nature structural & molecular biology

Abbr.

Nat Struct Mol Biol

ISSN

1545-9993

DOI

10.1038/nsmb1218

Published

2007-04-00

Epub

2007-00-25

Pages

347-8

Language

English

Region

United States

NLM ID

101186374

Subset

Grants

NIGMS NIH HHS · GM0720777 · United States

NINDS NIH HHS · NS053839 · United States

NICHD NIH HHS · P30-HD026979 · United States

Corrections

CommentIn

PMID: 17410089

External Links

PubMed source DOI: 10.1038/nsmb1218 View journal details

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Mouse Piwi-interacting RNAs are 2'-O-methylated at their 3' termini.

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