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PMID: 1738138 Published · ppublish English Journal Article Review

Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.

Journal of medicinal chemistry ·Vol. 35 ·No. 3 ·1992-02-07 ·Pages 407-22

Jacobson KA, van Galen PJ, Williams M

Abstract

暂无摘要

MeSH Terms
Adenosine/antagonists & inhibitors Animals Humans Models, Chemical Receptors, Purinergic/drug effects,genetics,physiology Second Messenger Systems Structure-Activity Relationship
Chemicals
Receptors, Purinergic Adenosine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Jacobson K A
Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, Bethesda, Maryland 20892.
van Galen P J
Williams M
References (132)
132 references, click to expand
  1. RDC8 codes for an adenosine A2 receptor with physiological constitutive activity.
    Biochem Biophys Res Commun. 1990 Dec 31;173(3):1169-78 PMID: 2125216
  2. Interaction of amiloride and its analogues with adenosine A1 receptors in calf brain.
    Biochem Pharmacol. 1990 Aug 15;40(4):827-34 PMID: 2143655
  3. The adenosine/neutrophil paradox resolved: human neutrophils possess both A1 and A2 receptors that promote chemotaxis and inhibit O2 generation, respectively.
    J Clin Invest. 1990 Apr;85(4):1150-7 PMID: 2156895
  4. Receptor triggering and receptor regulation: structure-activity relationships from the receptor's point of view.
    J Med Chem. 1990 May;33(5):1275-81 PMID: 2158558
  5. Allosteric enhancement of adenosine A1 receptor binding and function by 2-amino-3-benzoylthiophenes.
    Mol Pharmacol. 1990 Dec;38(6):939-49 PMID: 2174510
  6. Binding of the A1-selective adenosine antagonist 8-cyclopentyl-1,3-dipropylxanthine to rat brain membranes.
    Naunyn Schmiedebergs Arch Pharmacol. 1987 Jan;335(1):59-63 PMID: 3574492
  7. The physiological activity of adenine compounds with especial reference to their action upon the mammalian heart.
    J Physiol. 1929 Nov 25;68(3):213-37 PMID: 16994064
  8. A1 adenosine-receptor antagonists activate chloride efflux from cystic fibrosis cells.
    Proc Natl Acad Sci U S A. 1992 Jun 15;89(12):5562-6 PMID: 1376923
  9. Adenosine A1 and A2 receptors: structure--function relationships.
    Med Res Rev. 1992 Sep;12(5):423-71 PMID: 1513184
  10. Imidazodiazepinediones: a new class of adenosine receptor antagonists.
    J Med Chem. 1990 Oct;33(10):2818-21 PMID: 2213834
  11. 7-Deaza-2-phenyladenines: structure-activity relationships of potent A1 selective adenosine receptor antagonists.
    J Med Chem. 1990 Oct;33(10):2822-8 PMID: 2213835
  12. Adenosine. Renewed interest in an old drug.
    Circulation. 1990 Nov;82(5):1854-6 PMID: 2225382
  13. Structure-activity relationships for enhancement of adenosine A1 receptor binding by 2-amino-3-benzoylthiophenes.
    Mol Pharmacol. 1990 Dec;38(6):950-8 PMID: 2250667
  14. A novel synthesis of xanthines: support for a new binding mode for xanthines with respect to adenosine at adenosine receptors.
    J Med Chem. 1990 Dec;33(12):3127-30 PMID: 2258897
  15. The adenosine analog, 5'-N-ethylcarboxamidoadenosine, exerts mixed agonist action on cardiorespiratory parameters in the intact but not decerebrate rat following microinjections into the nucleus tractus solitarius.
    Brain Res. 1990 Oct 15;530(1):54-72 PMID: 2271953
  16. Purification and characterization of bovine cerebral cortex A1 adenosine receptor.
    Arch Biochem Biophys. 1990 Dec;283(2):440-6 PMID: 2275555
  17. Use of ATP following shock and ischemia.
    Ann N Y Acad Sci. 1990;603:130-40; discussion 140-1 PMID: 2291515
  18. Mechanisms of anticancer activities of adenine nucleotides in tumor-bearing hosts.
    Ann N Y Acad Sci. 1990;603:142-9; discussion 149-50 PMID: 2291516
  19. Dual control of local blood flow by purines.
    Ann N Y Acad Sci. 1990;603:31-44; discussion 44-5 PMID: 2291529
  20. Demonstration of both A1 and A2 adenosine receptors in DDT1 MF-2 smooth muscle cells.
    Mol Pharmacol. 1990 Feb;37(2):149-56 PMID: 2304450
  21. Adenosine A1 receptor mediated protection of the globally ischemic isolated rat heart.
    J Mol Cell Cardiol. 1990 Jan;22(1):39-47 PMID: 2325132
  22. Stimulation of nerve growth factor synthesis/secretion by propentofylline in cultured mouse astroglial cells.
    Biochem Pharmacol. 1990 Jun 1;39(11):1813-6 PMID: 2344376
  23. 2-(Arylalkylamino)adenosin-5'-uronamides: a new class of highly selective adenosine A2 receptor ligands.
    J Med Chem. 1990 Jul;33(7):1919-24 PMID: 2362269
  24. Diagnosis of coronary artery disease by controlled coronary vasodilation with adenosine and thallium-201 scintigraphy in patients unable to exercise.
    Circulation. 1990 Jul;82(1):80-7 PMID: 2364527
  25. 4-Amino[1,2,4]triazolo[4,3-a]quinoxalines. A novel class of potent adenosine receptor antagonists and potential rapid-onset antidepressants.
    J Med Chem. 1990 Aug;33(8):2240-54 PMID: 2374150
  26. Glycoprotein nature of the A2-adenosine receptor binding subunit.
    Mol Pharmacol. 1990 Aug;38(2):177-83 PMID: 2385230
  27. Adenosine and its analogue (-)-N6-R-phenyl-isopropyladenosine modulate anterior pituitary adenylate cyclase activity and prolactin secretion in the rat.
    J Mol Endocrinol. 1990 Aug;5(1):69-76 PMID: 2397024
  28. Adenosine receptors and calcium: basis for proposing a third (A3) adenosine receptor.
    Prog Neurobiol. 1986;26(3):179-209 PMID: 2425391
  29. Comparison of the behavioral effects of adenosine agonists and dopamine antagonists in mice.
    Psychopharmacology (Berl). 1989;98(1):31-7 PMID: 2498959
  30. Palmitoylation of the human beta 2-adrenergic receptor. Mutation of Cys341 in the carboxyl tail leads to an uncoupled nonpalmitoylated form of the receptor.
    J Biol Chem. 1989 May 5;264(13):7564-9 PMID: 2540197
  31. Purification of A1 adenosine receptor from rat brain membranes.
    J Biol Chem. 1989 Oct 5;264(28):16545-51 PMID: 2550448
  32. Increased adenosine concentration in blood from ischemic myocardium by AICA riboside. Effects on flow, granulocytes, and injury.
    Circulation. 1989 Nov;80(5):1400-11 PMID: 2553298
  33. Solubilities of adenosine antagonists determined by radioreceptor assay.
    J Pharm Pharmacol. 1989 Sep;41(9):590-4 PMID: 2573701
  34. [3H]CGS 21680, a selective A2 adenosine receptor agonist directly labels A2 receptors in rat brain.
    J Pharmacol Exp Ther. 1989 Dec;251(3):888-93 PMID: 2600819
  35. Coomassie Brilliant Blue G is a more potent antagonist of P2 purinergic responses than Reactive Blue 2 (Cibacron Blue 3GA) in rat parotid acinar cells.
    Biochem Biophys Res Commun. 1989 Dec 29;165(3):1279-85 PMID: 2610693
  36. Adenosine antagonists.
    Med Res Rev. 1989 Apr-Jun;9(2):219-43 PMID: 2654523
  37. Adenosine receptor prodrugs: towards kidney-selective dialkylxanthines.
    J Pharmacol Exp Ther. 1989 Jul;250(1):79-85 PMID: 2746513
  38. Demonstration of distinct agonist and antagonist conformations of the A1 adenosine receptor.
    J Biol Chem. 1989 Aug 5;264(22):13157-64 PMID: 2753906
  39. Identification of the A2 adenosine receptor binding subunit by photoaffinity crosslinking.
    Proc Natl Acad Sci U S A. 1989 Sep;86(17):6572-6 PMID: 2771944
  40. Agonist activity of 2- and 5'-substituted adenosine analogs and their N6-cycloalkyl derivatives at A1- and A2-adenosine receptors coupled to adenylate cyclase.
    Biochem Pharmacol. 1992 Mar 3;43(5):1089-93 PMID: 1554381
  41. Characterization of human striatal A2-adenosine receptors using radioligand binding and photoaffinity labeling.
    J Recept Res. 1992;12(2):149-69 PMID: 1583620
  42. Chemical modification and irreversible inhibition of striatal A2a adenosine receptors.
    Mol Pharmacol. 1992 Jul;42(1):123-33 PMID: 1635550
  43. The orphan receptor cDNA RDC7 encodes an A1 adenosine receptor.
    EMBO J. 1991 Jul;10(7):1677-82 PMID: 1646713
  44. Functional expression of P2Y purinoceptor in Xenopus oocyte injected with brain mRNA.
    Pflugers Arch. 1991 Jun;418(5):447-52 PMID: 1653942
  45. Non-xanthine heterocycles: activity as antagonists of A1- and A2-adenosine receptors.
    Biochem Pharmacol. 1988 Feb 15;37(4):655-64 PMID: 2829919
  46. Extracellular ATP increases free cytosolic calcium in rat parotid acinar cells. Differences from phospholipase C-linked receptor agonists.
    Biochem J. 1988 Oct 1;255(1):291-300 PMID: 2848507
  47. How does adenosine inhibit transmitter release?
    Trends Pharmacol Sci. 1988 Apr;9(4):130-4 PMID: 2907698
  48. 1,3-Dialkyl-8-(p-sulfophenyl)xanthines: potent water-soluble antagonists for A1- and A2-adenosine receptors.
    J Med Chem. 1985 Apr;28(4):487-92 PMID: 2984420
  49. The A1 adenosine receptor. Identification of the binding subunit by photoaffinity cross-linking.
    J Biol Chem. 1985 Sep 5;260(19):10806-11 PMID: 2993290
  50. Functionalized congeners of 1,3-dialkylxanthines: preparation of analogues with high affinity for adenosine receptors.
    J Med Chem. 1985 Sep;28(9):1334-40 PMID: 2993622
  51. Specific photoaffinity labelling of inhibitory adenosine receptors.
    Biochem Biophys Res Commun. 1985 Aug 30;131(1):115-21 PMID: 2994642
  52. Xanthine derivatives as antagonists at A1 and A2 adenosine receptors.
    Naunyn Schmiedebergs Arch Pharmacol. 1985 Sep;330(3):212-21 PMID: 2997628
  53. Ribose-modified adenosine analogues as adenosine receptor agonists.
    J Med Chem. 1986 Mar;29(3):346-53 PMID: 3005574
  54. A functionalized congener approach to adenosine receptor antagonists: amino acid conjugates of 1,3-dipropylxanthine.
    Mol Pharmacol. 1986 Feb;29(2):126-33 PMID: 3005825
  55. Extracellular ATP: effects, sources and fate.
    Biochem J. 1986 Jan 15;233(2):309-19 PMID: 3006665
  56. Characterization of the A2 adenosine receptor labeled by [3H]NECA in rat striatal membranes.
    Mol Pharmacol. 1986 Apr;29(4):331-46 PMID: 3010074
  57. Photoaffinity cross-linked A1 adenosine receptor-binding subunits. Homologous glycoprotein expression by different tissues.
    J Biol Chem. 1986 Aug 15;261(23):10839-43 PMID: 3015944
  58. An investigation of the low intrinsic activity of adenosine and its analogs at low affinity (A2) adenosine receptors in rat cerebral cortex.
    J Neurochem. 1986 Aug;47(2):547-53 PMID: 3016175
  59. Structure-activity relationships for N6-substituted adenosines at a brain A1-adenosine receptor with a comparison to an A2-adenosine receptor regulating coronary blood flow.
    Biochem Pharmacol. 1986 Aug 1;35(15):2467-81 PMID: 3017353
  60. Agonist photoaffinity labeling of A1 adenosine receptors: persistent activation reveals spare receptors.
    Mol Pharmacol. 1986 Oct;30(4):403-9 PMID: 3020390
  61. A1 adenosine receptor-G protein coupling in bovine brain membranes: effects of guanine nucleotides, salt, and solubilization.
    J Neurochem. 1988 Nov;51(5):1592-8 PMID: 3139838
  62. Benzo[1,2-c:5,4-c']dipyrazoles: non-xanthine adenosine antagonists.
    J Med Chem. 1988 Oct;31(10):2034-9 PMID: 3172141
  63. 2-aralkoxyadenosines: potent and selective agonists at the coronary artery A2 adenosine receptor.
    J Med Chem. 1991 Apr;34(4):1340-4 PMID: 2016708
  64. Mechanism of A2 adenosine receptor activation. I. Blockade of A2 adenosine receptors by photoaffinity labeling.
    Mol Pharmacol. 1991 Apr;39(4):517-23 PMID: 2017151
  65. Novel therapeutics acting via purine receptors.
    Biochem Pharmacol. 1991 May 15;41(10):1399-410 PMID: 2018549
  66. Purinergic regulation of bradykinin-induced plasma extravasation and adjuvant-induced arthritis in the rat.
    Proc Natl Acad Sci U S A. 1991 May 15;88(10):4162-5 PMID: 2034661
  67. Further subclassification of ATP receptors based on agonist studies.
    Trends Pharmacol Sci. 1991 Apr;12(4):137-41 PMID: 2063479
  68. Inhibition of nucleoside uptake in human erythrocytes by a new series of compounds related to lidoflazine and mioflazine.
    Eur J Pharmacol. 1990 Dec 15;189(6):419-22 PMID: 2073930
  69. Pentoxifylline does not act via adenosine receptors in the inhibition of the superoxide anion production of human polymorphonuclear leukocytes.
    Biochem Biophys Res Commun. 1991 Oct 15;180(1):53-8 PMID: 1656978
  70. Molecular cloning and characterization of a rat A1-adenosine receptor that is widely expressed in brain and spinal cord.
    Mol Endocrinol. 1991 Aug;5(8):1037-48 PMID: 1658635
  71. GABAA receptor modulation of memory: the role of endogenous benzodiazepines.
    Trends Pharmacol Sci. 1991 Jul;12(7):260-5 PMID: 1658996
  72. Brain adenosine and transmitter amino acid release from the ischemic rat cerebral cortex: effects of the adenosine deaminase inhibitor deoxycoformycin.
    J Neurochem. 1991 Feb;56(2):644-50 PMID: 1671090
  73. Nucleotide modulation of norepinephrine release from sympathetic nerves in the rat vas deferens.
    J Pharmacol Exp Ther. 1991 Mar;256(3):821-6 PMID: 1672377
  74. Structure-activity relationships of 8-cycloalkyl-1,3-dipropylxanthines as antagonists of adenosine receptors.
    J Med Chem. 1990 Jul;33(7):1906-10 PMID: 1694546
  75. Signal transduction by P2-purinergic receptors for extracellular ATP.
    Am J Respir Cell Mol Biol. 1991 Apr;4(4):295-300 PMID: 1707633
  76. Pentoxifylline and other methyl xanthines inhibit interleukin-2 receptor expression in human lymphocytes.
    Cell Immunol. 1991 Jul;135(2):314-25 PMID: 1709825
  77. Activity of N6-substituted 2-chloroadenosines at A1 and A2 adenosine receptors.
    J Med Chem. 1991 Dec;34(12):3388-90 PMID: 1766003
  78. Contamination of adenosine deaminase by superoxide dismutase. Stabilization of endothelium-derived relaxing factor.
    Biochem Pharmacol. 1991 Jan 15;41(2):273-9 PMID: 1846547
  79. Adenosine inhibits excitatory but not inhibitory synaptic transmission in the hippocampus.
    J Neurosci. 1991 May;11(5):1375-80 PMID: 1851219
  80. Cloning and expression of an A1 adenosine receptor from rat brain.
    Mol Pharmacol. 1991 Jul;40(1):1-7 PMID: 1857334
  81. Activation by extracellular nucleotides of chloride secretion in the airway epithelia of patients with cystic fibrosis.
    N Engl J Med. 1991 Aug 22;325(8):533-8 PMID: 1857389
  82. Adenosine. The signal of life?
    Circulation. 1991 Aug;84(2):951-4 PMID: 1860244
  83. The antihypertensive effect of 2-alkynyladenosines and their selective affinity for adenosine A2 receptors.
    Eur J Pharmacol. 1991 Apr 10;196(1):69-76 PMID: 1874281
  84. Highly selective adenosine A2 receptor agonists in a series of N-alkylated 2-aminoadenosines.
    J Med Chem. 1991 Aug;34(8):2570-9 PMID: 1875349
  85. The A2 adenosine receptor: guanine nucleotide modulation of agonist binding is enhanced by proteolysis.
    Mol Pharmacol. 1991 Feb;39(2):130-5 PMID: 1899902
  86. Behavioral effects of A1- and A2-selective adenosine agonists and antagonists: evidence for synergism and antagonism.
    J Pharmacol Exp Ther. 1991 Oct;259(1):286-94 PMID: 1920121
  87. Cardiovascular actions of adenosines, but not adenosine receptors, differ in rat and guinea pig.
    Life Sci. 1991;49(18):1351-8 PMID: 1921650
  88. Excitatory amino acid receptors in the brain: membrane binding and receptor autoradiographic approaches.
    Trends Pharmacol Sci. 1990 Mar;11(3):126-33 PMID: 1966569
  89. Overview. Purinergic mechanisms.
    Ann N Y Acad Sci. 1990;603:1-17; discussion 18 PMID: 1981306
  90. Purine nucleosides and nucleotides as central nervous system modulators. Adenosine as the prototypic paracrine neuroactive substance.
    Ann N Y Acad Sci. 1990;603:93-107 PMID: 1981308
  91. Reduction of myocardial reperfusion injury by intravenous adenosine administered during the early reperfusion period.
    Circulation. 1991 Jan;83(1):237-47 PMID: 1984882
  92. 8-(Dicyclopropylmethyl)-1,3-dipropylxanthine: a potent and selective adenosine A1 antagonist with renal protective and diuretic activities.
    J Med Chem. 1991 Jan;34(1):466-9 PMID: 1992150
  93. A new fluorescent probe for the equilibrative inhibitor-sensitive nucleoside transporter. 5'-S-(2-aminoethyl)-N6-(4-nitrobenzyl)-5'-thioadenosine (SAENTA)-chi 2-fluorescein.
    Biochem J. 1991 Feb 1;273 ( Pt 3):667-72 PMID: 1996965
  94. 1H-imidazo[4,5-c]quinolin-4-amines: novel non-xanthine adenosine antagonists.
    J Med Chem. 1991 Mar;34(3):1202-6 PMID: 2002461
  95. Methotrexate inhibits neutrophil function by stimulating adenosine release from connective tissue cells.
    Proc Natl Acad Sci U S A. 1991 Mar 15;88(6):2441-5 PMID: 2006182
  96. Identification of a unique membrane receptor for adenosine 5',5"'-P1,P4-tetraphosphate.
    J Biol Chem. 1991 Apr 15;266(11):6915-8 PMID: 2016305
  97. Extracellular ATP and adenosine modulate tumor necrosis factor-induced lysis of L929 cells in the presence of actinomycin D.
    J Immunol. 1991 Apr 15;146(8):2708-11 PMID: 2016524
  98. 2-Alkoxyadenosines: potent and selective agonists at the coronary artery A2 adenosine receptor.
    J Med Chem. 1991 Apr;34(4):1334-9 PMID: 2016707
  99. Inhibition of nucleoside transport by a new series of compounds related to lidoflazine and mioflazine.
    Eur J Pharmacol. 1989 Aug 15;172(3):273-81 PMID: 2776845
  100. CGS 21680C, an A2 selective adenosine receptor agonist with preferential hypotensive activity.
    J Pharmacol Exp Ther. 1989 Oct;251(1):47-55 PMID: 2795469
  101. Linear and proximal benzo-separated alkylated xanthines as adenosine-receptor antagonists.
    J Med Chem. 1989 Oct;32(10):2247-54 PMID: 2795597
  102. Adenosine and pituitary-adrenocortical axis activity in the rat.
    Neuroendocrinology. 1989 Oct;50(4):464-8 PMID: 2812276
  103. Cardiovascular purinoceptors.
    Physiol Rev. 1990 Jul;70(3):761-845 PMID: 2194223
  104. Chemical modification of A1 adenosine receptors in rat brain membranes. Evidence for histidine in different domains of the ligand binding site.
    J Biol Chem. 1988 Nov 25;263(33):17522-6 PMID: 3182861
  105. High affinity acylating antagonists for the A1 adenosine receptor: identification of binding subunit.
    Mol Pharmacol. 1988 Dec;34(6):724-8 PMID: 3200248
  106. 2-Chloro-N6-cyclopentyladenosine: a highly selective agonist at A1 adenosine receptors.
    Naunyn Schmiedebergs Arch Pharmacol. 1988 Jun;337(6):687-9 PMID: 3216901
  107. Two adjacent cysteine residues in the C-terminal cytoplasmic fragment of bovine rhodopsin are palmitylated.
    FEBS Lett. 1988 Mar 28;230(1-2):1-5 PMID: 3350146
  108. [1,2,4]Triazolo[4,3-a]quinoxalin-4-amines: a new class of A1 receptor selective adenosine antagonists.
    J Med Chem. 1988 May;31(5):1011-4 PMID: 3361571
  109. Structure-activity profile of a series of novel triazoloquinazoline adenosine antagonists.
    J Med Chem. 1988 May;31(5):1014-20 PMID: 3361572
  110. Adenosine receptor agonists: synthesis and biological evaluation of 1-deaza analogues of adenosine derivatives.
    J Med Chem. 1988 Jun;31(6):1179-83 PMID: 3373486
  111. 125I-BW-A844U, an antagonist radioligand with high affinity and selectivity for adenosine A1 receptors, and 125I-azido-BW-A844U, a photoaffinity label.
    Mol Pharmacol. 1988 Jun;33(6):585-91 PMID: 3380075
  112. An adenosine analogue, 2-chloroadenosine, protects against long term development of ischaemic cell loss in the rat hippocampus.
    Neurosci Lett. 1987 Dec 29;83(3):287-92 PMID: 3441311
  113. N6-substituted 9-methyladenines: a new class of adenosine receptor antagonists.
    FEBS Lett. 1987 May 11;215(2):203-8 PMID: 3582647
  114. A new high affinity, iodinated adenosine receptor antagonist as a radioligand/photoaffinity crosslinking probe.
    Mol Pharmacol. 1987 Aug;32(1):184-8 PMID: 3614192
  115. The glycoprotein nature of A1 adenosine receptors.
    Biochem Biophys Res Commun. 1986 Oct 15;140(1):406-13 PMID: 3778456
  116. Analogues of caffeine and theophylline: effect of structural alterations on affinity at adenosine receptors.
    J Med Chem. 1986 Jul;29(7):1305-8 PMID: 3806581
  117. Synthesis and structure-activity relationships of pyrazolo[4,3-d]pyrimidin-7-ones as adenosine receptor antagonists.
    J Med Chem. 1987 Jan;30(1):91-6 PMID: 3806606
  118. Is adenosine an endogenous anticonvulsant?
    Epilepsia. 1985 Sep-Oct;26(5):480-7 PMID: 4043018
  119. The effect of adenosine and adenine nucleotides on the cyclic adenosine 3', 5'-phosphate content of guinea pig cerebral cortex slices.
    Mol Pharmacol. 1970 Jan;6(1):13-23 PMID: 4354003
  120. Adenosine receptor activation in human fibroblasts: nucleoside agonists and antagonists.
    Can J Physiol Pharmacol. 1980 Jun;58(6):673-91 PMID: 6253037
  121. Adenosine antagonism by purines, pteridines and benzopteridines in human fibroblasts.
    Biochem Pharmacol. 1981 Feb 15;30(4):325-33 PMID: 6260118
  122. Adenosine receptors: targets for future drugs.
    J Med Chem. 1982 Mar;25(3):197-207 PMID: 6279840
  123. CGS 8216: receptor binding characteristics of a potent benzodiazepine antagonist.
    Life Sci. 1982 Jan 25;30(4):363-72 PMID: 6280007
  124. Inhibition by etazolate (SQ 20009) and cartazolate (SQ 65396) of adenosine-stimulated [3H]cAMP formation in [2-3H]adenine-prelabeled vesicles prepared from guinea pig cerebral cortex.
    Biochem Pharmacol. 1982 Apr 1;31(7):1441-2 PMID: 6284176
  125. Pyrazolo[3,4-d]pyrimidines as adenosine antagonists.
    Life Sci. 1984 May 28;34(22):2117-28 PMID: 6328156
  126. Sedative and anticonvulsant effects of adenosine analogs in mouse and rat.
    J Pharmacol Exp Ther. 1982 Jan;220(1):70-6 PMID: 7053424
  127. A purinergic component in the anticonvulsant action of carbamazepine?
    Eur J Pharmacol. 1982 Aug 27;82(3-4):195-7 PMID: 7128687
  128. Coronary and cardiohemodynamic effects of 2-phenylamino-adenosine (CV-1808) in anesthetized dogs and cats.
    Arzneimittelforschung. 1980;30(7):1083-7 PMID: 7191290
  129. Adenosine: The prototypic neuromodulator.
    Neurochem Int. 1989;14(3):249-64 PMID: 20504426
  130. Functional activity of the adenosine binding enhancer, PD 81,723, in the in vitro hippocampal slice.
    Brain Res. 1991 Dec 20;567(2):181-7 PMID: 1817724
  131. Mapping the N6-region of the adenosine A1 receptor with computer graphics.
    Eur J Pharmacol. 1989 Mar 7;172(1):19-27 PMID: 2714369
  132. Affinities of barbiturates for the GABA-receptor complex and A1 adenosine receptors: a possible explanation of their excitatory effects.
    Naunyn Schmiedebergs Arch Pharmacol. 1987 Aug;336(2):211-7 PMID: 2825044
Article Info
Journal
Journal of medicinal chemistry
Abbr.
J Med Chem
ISSN
0022-2623
DOI
10.1021/jm00081a001
Published
1992-02-07
Pages
407-22
Language
English
Region
United States
NLM ID
9716531
PMCID
PMC3476067
Subset
IM
Grants
Intramural NIH HHS · Z01 DK031117-20 · United States
Intramural NIH HHS · Z99 DK999999 · United States
External Links
PubMed source DOI: 10.1021/jm00081a001 PMC Full Text View journal details
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