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题目:: Fluctuation of the SP/non-SP phenotype in the C6 glioma cell line.
作者:: Platet(Nadine),Mayol(Jean-François),Berger(François),Hérodin(Francis),Wion(Didier)
状态:: 发布时间2007-03-27 , 更新时间 2016-11-24
期刊:: FEBS Lett
摘要:: Using the C6 glioma cell as a paradigm, we found that (i) the clonogenicity of C6 cells is several orders of magnitude higher than the percentage of SP cells; (ii) non-SP cells are able to generate SP cells, and conversely SP cells generate non-SP cells; (iii) non-SP sorted cells behave as tumorigenic cells. Hence, in C6 cells cultured in serum-containing medium, SP cells can be generated from non-SP cells. This dynamic equilibrium explains in C6 cells the maintenance of the SP phenotype with cell passaging and demonstrates the existence of tumorigenic non-SP cells.
语言:: eng
DOI:: 10.1016/j.febslet.2007.02.071

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