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PMID: 17353383 Published · ppublish English Comparative Study Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Measures of adiposity and dementia risk in elderly persons.

Archives of neurology ·Vol. 64 ·No. 3 ·2007-03-00 ·Pages 392-8

Luchsinger JA, Patel B, Tang MX, Schupf N, Mayeux R

Abstract

Studies relating adiposity to dementia are conflicting. We explored the associations of body mass index (BMI), (calculated as weight in kilograms divided by the square of height in meters) waist circumference, and weight change to dementia, probable Alzheimer disease, and dementia associated with stroke (DAS). Persons without dementia were followed up for 5 years; 893 persons had BMI data, 907 had waist circumference data, and 709 had a second weight measurement. Dementia was ascertained using standard methods. Cox proportional hazards regression was used for analyses using follow-up as time to event, adjusting for demographics and apolipoprotein E-epsilon4 status. Compared with persons in the first quartile of BMI, persons in the third quartile had a lower dementia and Alzheimer disease risk and persons in the second quartile had a lower DAS risk. The association between BMI and dementia resembled a U shape in those younger than 76 years, while dementia risk decreased with higher BMI in those 76 years and older. The fourth quartile of waist circumference was related to a higher DAS risk in the whole sample, and to dementia and Alzheimer disease in persons younger than 76 years. Weight loss was related to a higher dementia and DAS risk, and weight gain was related to a higher DAS risk only. The prospective association between adiposity and dementia differs depending on the anthropometric measure used, and is modified by age. This may explain previous conflicting reports.

MeSH Terms
Adipose Tissue/metabolism Adiposity Aged Aged, 80 and over Body Mass Index Dementia/epidemiology,metabolism,physiopathology Female Geriatric Assessment Humans Longitudinal Studies Male Proportional Hazards Models Risk
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Luchsinger José A
Taub Institute for Research of Alzheimer's Disease and the Aging Brain, Columbia University, 630 W 168th St, New York, NY 10032, USA. jal94@columbia.edu
Patel Bindu
Tang Ming-Xin
Schupf Nicole
Mayeux Richard
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Article Info
Journal
Archives of neurology
Abbr.
Arch Neurol
ISSN
0003-9942
DOI
10.1001/archneur.64.3.392
Email
jal94@columbia.edu
Published
2007-03-00
Pages
392-8
Language
English
Region
United States
NLM ID
0372436
PMCID
PMC1821350
Subset
IM
Grants
NIA NIH HHS · K08 AG020856 · United States
NCRR NIH HHS · M01 RR000645 · United States
NIA NIH HHS · 1K08AG20856-01 · United States
NCRR NIH HHS · RR00645 · United States
NIA NIH HHS · P01 AG007232 · United States
NIA NIH HHS · AG07232 · United States
NIA NIH HHS · AG07702 · United States
External Links
PubMed source DOI: 10.1001/archneur.64.3.392 PMC Full Text View journal details
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