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PMID: 17340208 Published · ppublish English Journal Article

The investigation of GSTT1, GSTM1 and SOD polymorphism in bladder cancer patients.

International urology and nephrology ·Vol. 39 ·No. 4 ·2007-00-00 ·Pages 1043-8

Cengiz M, Ozaydin A, Ozkilic AC, Dedekarginoglu G

Abstract

Glutathione S transferases (GSTT1, GSTM1, GSTP1) are enzymes that activate the detoxification of endogenous and exogenous agents. The genetic polymorphism in these genes may change the response of individuals to environmental toxicants. The genetic polymorphisms of GSTT1, GSTM1, GSTP1 have been studied extensively in the determination of individual cancer risks. Some studies showed a strong relationship between polymorphism of GSTs and superoxidedismutase enzymes. Using the polymerase chain reaction (PCR) the prevalence of genetic polymorphisms of GSTT1, GSTM1 and MnSOD (Manganese Superoxide Dismurase) was investigated in 104 cases and controls to seek any association with the risk of bladder cancer. The frequency of GSTT1 +/+ polymorphism was 65% (33/51) in the cases and 79% (42/53) in the controls. The frequency of the GSTM1 +/+ polymorphism was 33% (17/51) in the cases and 58% (31/53) in the controls. The frequency of the GSTM1 null genotype was 42% (22/53) in the controls and 68% (34/51) in the patients. The frequency of the SOD AA genotype was 36% (17/51) in the cases and 33% (19/53) in the controls. There was no association between the GSTT1 and SOD polymorphism and bladder cancer incidence. The incidence of the GSTM1 null genotype was increased in bladder cancer patients compared to controls (OR = 1.755, 95% CI = 1.119-2.751).

MeSH Terms
Case-Control Studies Female Genotype Glutathione Transferase/genetics Humans Male Middle Aged Polymerase Chain Reaction Polymorphism, Genetic Statistics, Nonparametric Superoxide Dismutase/genetics Urinary Bladder Neoplasms/enzymology,genetics
Chemicals
Superoxide Dismutase superoxide dismutase 2 glutathione S-transferase T1 Glutathione Transferase glutathione S-transferase M1
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Cengiz Müjgan
Department Of Medical Biology, Cerrahpaşa Medical Faculty, Istanbul University, Istanbul, Turkey.
Ozaydin Ahmet
Ozkilic Anil Cagla
Dedekarginoglu Galip
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Article Info
Journal
International urology and nephrology
Abbr.
Int Urol Nephrol
ISSN
0301-1623
DOI
10.1007/s11255-007-9179-9
Published
2007-00-00
Epub
2007-00-06
Pages
1043-8
Language
English
Region
Netherlands
NLM ID
0262521
Subset
IM
External Links
PubMed source DOI: 10.1007/s11255-007-9179-9 View journal details
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