Home LiteratureArticle Details
PMID: 17332880 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Infectious disease, the innate immune response, and fibrosis.

The Journal of clinical investigation ·Vol. 117 ·No. 3 ·2007-03-00 ·Pages 530-8

Meneghin A, Hogaboam CM

Abstract

The unrelenting and destructive progression of most fibrotic responses in the pulmonary, cardiovascular, integumentary, and alimentary systems remains a major medical challenge for which therapies are desperately needed. The pathophysiology of fibrosis remains an enigma, but considerable research and debate surrounds the question of whether chronic inflammation is the key driver of unrestrained wound healing (i.e., the fibrotic response) in these and other organ systems. This Review describes how infectious pathogens, chronic inflammation, and unrestrained fibroproliferation are likely to be part of a dynamic, unrelenting process propelling human fibrotic diseases.

MeSH Terms
Cicatrix/pathology Communicable Diseases/complications,microbiology,parasitology Fibrosis/etiology,immunology,microbiology Humans Immunity, Innate Wound Healing
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Meneghin Alessia
Immunology Program, Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Hogaboam Cory M
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Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI30595
Published
2007-03-00
Pages
530-8
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC1804377
Subset
IM
Grants
NHLBI NIH HHS · P50 HL056402 · United States
NHLBI NIH HHS · R01 HL073728 · United States
NHLBI NIH HHS · R01 HL69865 · United States
NHLBI NIH HHS · P50 HL56402 · United States
NHLBI NIH HHS · R01 HL069865 · United States
External Links
PubMed source DOI: 10.1172/JCI30595 PMC Full Text View journal details
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