Ten genes for inherited breast cancer.

Cancer cell ·Vol. 11 ·No. 2 ·2007-02-00 ·Pages 103-5

Walsh T, King MC

Abstract

Inherited breast cancer is associated with germline mutations in ten different genes in pathways critical to genomic integrity. BRCA1 and BRCA2 mutations confer very high risks of breast and ovarian cancer. p53 and PTEN mutations lead to very high breast cancer risks associated with rare cancer syndromes. Mutations in CHEK2, ATM, NBS1, RAD50, BRIP1, and PALB2 are associated with doubling of breast cancer risks. In addition, biallelic mutations in BRCA2, BRIP1, and PALB2 cause Fanconi anemia. The convergence of these genes in a shared role reveals underlying biology of these illnesses and suggests still other breast cancer genes.

MeSH Terms

Acid Anhydride Hydrolases Ataxia Telangiectasia Mutated Proteins BRCA1 Protein/genetics,metabolism BRCA2 Protein/genetics,metabolism Breast Neoplasms/genetics Cell Cycle Proteins/genetics,metabolism Checkpoint Kinase 2 DNA Repair Enzymes/genetics,metabolism DNA-Binding Proteins/genetics,metabolism Fanconi Anemia/genetics Fanconi Anemia Complementation Group N Protein Fanconi Anemia Complementation Group Proteins Genetic Predisposition to Disease Germ-Line Mutation/genetics Humans Neoplasm Proteins/genetics,metabolism Nuclear Proteins/genetics,metabolism PTEN Phosphohydrolase/genetics,metabolism Protein Serine-Threonine Kinases/genetics,metabolism RNA Helicases/genetics,metabolism Tumor Suppressor Protein p53/genetics,metabolism Tumor Suppressor Proteins/genetics,metabolism

Chemicals

BRCA1 Protein BRCA2 Protein Cell Cycle Proteins DNA-Binding Proteins Fanconi Anemia Complementation Group N Protein Fanconi Anemia Complementation Group Proteins NBN protein, human Neoplasm Proteins Nuclear Proteins PALB2 protein, human Tumor Suppressor Protein p53 Tumor Suppressor Proteins Checkpoint Kinase 2 ATM protein, human Ataxia Telangiectasia Mutated Proteins CHEK2 protein, human Protein Serine-Threonine Kinases PTEN Phosphohydrolase PTEN protein, human Acid Anhydride Hydrolases Rad50 protein, human BRIP1 protein, human RNA Helicases DNA Repair Enzymes

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Walsh Tom

Department of Medicine, University of Washington, Seattle, Washington 98195, USA. twalsh@u.washington.edu

King Mary-Claire

Article Info

Journal

Cancer cell

Abbr.

Cancer Cell

ISSN

1535-6108

DOI

10.1016/j.ccr.2007.01.010

twalsh@u.washington.edu

Published

2007-02-00

Pages

103-5

Language

English

Region

United States

NLM ID

101130617

Subset

External Links

PubMed source DOI: 10.1016/j.ccr.2007.01.010 View journal details

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