Protective effect of liposome-entrapped superoxide dismutase and catalase on bleomycin-induced lung injury in rats. II. Phospholipids of the lung surfactant.

Acta physiologica Hungarica ·Vol. 78 ·No. 2 ·1991-00-00 ·Pages 157-62

Ledwozyw A

Abstract

The influence of liposome-entrapped catalase and/or superoxide dismutase on phospholipids of the lung surfactant in bleomycin-treated rats was investigated. Changes in phospholipid composition of lung surfactant were much pronounced in animals supplemented with antioxidant enzymes-loaded liposomes. It is suggested that liposomes are good carriers for drugs in bleomycin-induced lung injury treatment.

MeSH Terms

Animals Bleomycin Bronchoalveolar Lavage Fluid/chemistry Catalase/pharmacology Chromatography, Thin Layer Drug Carriers Liposomes Male Phospholipids/metabolism Pulmonary Fibrosis/chemically induced,metabolism,prevention & control Pulmonary Surfactants/metabolism Rats Rats, Inbred Strains Superoxide Dismutase/pharmacology

Chemicals

Drug Carriers Liposomes Phospholipids Pulmonary Surfactants Bleomycin Catalase Superoxide Dismutase

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Ledwozyw A

Department of Pathophysiology, Veterinary Faculty, Agricultural Academy, Lublin, Poland.

Article Info

Journal

Acta physiologica Hungarica

Abbr.

Acta Physiol Hung

ISSN

0231-424X

Published

1991-00-00

Pages

157-62

Language

English

Region

Hungary

NLM ID

8309201

Subset

External Links

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Protective effect of liposome-entrapped superoxide dismutase and catalase on bleomycin-induced lung injury in rats. II. Phospholipids of the lung surfactant.

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