Phosphoinositides specify polarity during epithelial organ development.

Cell ·Vol. 128 ·No. 2 ·2007-01-26 ·Pages 239-40

Comer FI, Parent CA

Abstract

The molecular mechanisms that integrate cellular polarity with tissue architecture during epithelial morphogenesis are poorly understood. Using a three-dimensional model of epithelial morphogenesis, report that the phosphatase PTEN and phosphatidylinositol (4,5)-bisphosphate [PI(4,5)P2] regulate the GTPase Cdc42 and the kinase aPKC to generate the apical plasma membrane domain and maintain apical-basolateral polarity.

MeSH Terms

Animals Cell Membrane/metabolism Cell Polarity/physiology Epithelium/embryology,metabolism,ultrastructure Humans Organogenesis/physiology PTEN Phosphohydrolase/metabolism Phosphatidylinositol Phosphates/metabolism Phosphatidylinositols/metabolism Protein Kinase C/metabolism Signal Transduction/physiology cdc42 GTP-Binding Protein/metabolism

Chemicals

Phosphatidylinositol Phosphates Phosphatidylinositols PKC-3 protein Protein Kinase C PTEN Phosphohydrolase cdc42 GTP-Binding Protein

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Comer Frank I

Laboratory of Cellular and Molecular Biology, Center for Cancer Research, NCI, NIH, 37 Convent Drive, Bldg. 37, Room 2066, Bethesda, MD 20892, USA.

Parent Carole A

Article Info

Journal

Cell

Abbr.

Cell

ISSN

0092-8674

DOI

10.1016/j.cell.2007.01.010

Published

2007-01-26

Pages

239-40

Language

English

Region

United States

NLM ID

0413066

Subset

Corrections

CommentOn

PMID: 17254974

External Links

PubMed source DOI: 10.1016/j.cell.2007.01.010 View journal details

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