Virus-induced diabetes mellitus. V. Biological differences between the M variant and other strains of encephalomyocarditis virus.

Infection and immunity ·Vol. 12 ·No. 5 ·1975-11-00 ·Pages 1224-6

Ross ME, Onodera T, Hayashi K, Notkins AL

Abstract

The M variant of encephalomyocarditis virus is very closely related serologically to five other strains of encephalomyocarditis virus. Despite the serological relationship, these five viruses differ markedly from the M variant in their tissue tropisms and only the M variant infects beta cells of the pancreas, producing diabetes.

MeSH Terms

Animals Antibodies, Viral/analysis Diabetes Complications Diabetes Mellitus/etiology,immunology Encephalomyocarditis virus/immunology,pathogenicity Enterovirus Infections/immunology Genetic Variation Male Mice Neutralization Tests

Chemicals

Antibodies, Viral

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Ross M E

Onodera T

Hayashi K

Notkins A L

References (5)

5 references, click to expand

Virus-induced diabetes mellitus. I. Hyperglycemia and hypoinsulinemia in mice infected with encephalomyocarditis virus.
J Exp Med. 1973 May 1;137(5):1226-39 PMID: 4349751
SOME PROPERTIES OF THE ENCEPHALOMYOCARDITIS, COLUMBIA SK AND MENGO VIRUSES.
Proc Soc Exp Biol Med. 1965 Jun;119:408-12 PMID: 14328905
Virus-induced diabetes mellitus. III. Influence of the sex and strain of the host.
J Infect Dis. 1975 Apr;131(4):462-6 PMID: 163872
Diabetes mellitus-like syndrome in mice infected with encephalomyocarditis virus.
Am J Pathol. 1971 Apr;63(1):119-34 PMID: 4323473
Encephalomyocarditis virus (E variant) in mice. Pancreatic changes.
Arch Pathol. 1973 May;95(5):304-11 PMID: 4348435

Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.12.5.1224-1226.1975

Published

1975-11-00

Pages

1224-6

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC415422

Subset

External Links

PubMed source DOI: 10.1128/iai.12.5.1224-1226.1975 PMC Full Text View journal details

Analysis Services

Virus-induced diabetes mellitus. V. Biological differences between the M variant and other strains of encephalomyocarditis virus.

Contact

WeChat Official Account