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题目:: Ito cells are liver-resident antigen-presenting cells for activating T cell responses.
作者:: Winau(Florian),Hegasy(Guido),Weiskirchen(Ralf),Weber(Stephan),Cassan(Cécile),Sieling(Peter A),Modlin(Robert L),Liblau(Roland S),Gressner(Axel M),Kaufmann(Stefan H E)
状态:: 发布时间2007-01-23 , 更新时间 2010-11-18
期刊:: Immunity
摘要:: Here we identified Ito cells (hepatic stellate cells, HSC), known for storage of vitamin A and participation in hepatic fibrosis, as professional liver-resident antigen-presenting cells (APC). Ito cells efficiently presented antigens to CD1-, major histocompatibility complex (MHC)-I-, and MHC-II-restricted T cells. Ito cells presented lipid antigens to CD1-restricted T lymphocytes such as natural killer T (NKT) cells and promoted homeostatic proliferation of liver NKT cells through interleukin-15. Moreover, Ito cells presented antigenic peptides to CD8(+) and CD4(+) T cells and mediated crosspriming of CD8(+) T cells. Peptide-specific T cells were activated by transgenic Ito cells presenting endogenous neoantigen. Upon bacterial infection, Ito cells elicited antigen-specific T cells and mediated protection. In contrast to other liver cell types that have been implicated in induction of immunological tolerance, our data identify Ito cells as professional intrahepatic APCs activating T cells and eliciting a multitude of T cell responses specific for protein and lipid antigens.
语言:: eng
DOI:: 10.1016/j.immuni.2006.11.011

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